Cytotoxic T cell function in fish

T. Nakanishi, U. Fischer, J. M. Dijkstra, S. Hasegawa, T. Somamoto, N. Okamoto, M. Ototake

研究成果: Article

110 引用 (Scopus)

抜粋

Fish possess immunoglobulins, major histocompatibility complex (MHC), T-cell receptors, and lymphocyte populations analogous to B and T cells and can evoke specific immune responses against a variety of antigens. However, T-cell subsets have yet to be demonstrated and the information on cell-mediated immunity is limited. Here we briefly review our recent studies on specific cell-mediated immunity, particularly on cytotoxic T-cell function employing isogeneic fish and cell lines. Analyses of the graft-versus host reaction (GVHR) and cell-mediated cytotoxicity (CMC) against allogeneic erythrocytes or cell lines show alloantigen-specific cytotoxicity in clonal ginbuna crucian carp. We also describe specific cytotoxicity against virus-infected cells using clonal ginbuna and a syngeneic cell line. Lastly, we report MHC-restriction in CMC against virus-infected cells using homozygous clonal rainbow trout and trout cell line which share the same MHC class I allele. These studies on CMC strongly suggest the presence of antigen specific cytotoxic T cells in teleosts and functional similarities between the immune systems of fish and higher vertebrates. Experimental model systems established in these studies can be applied to the investigation of protective antigens to induce cell-mediated immunity for the development of fish vaccines.

元の言語English
ページ(範囲)131-139
ページ数9
ジャーナルDevelopmental and Comparative Immunology
26
発行部数2
DOI
出版物ステータスPublished - 01-01-2002
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Immunology
  • Developmental Biology

フィンガープリント Cytotoxic T cell function in fish' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Nakanishi, T., Fischer, U., Dijkstra, J. M., Hasegawa, S., Somamoto, T., Okamoto, N., & Ototake, M. (2002). Cytotoxic T cell function in fish. Developmental and Comparative Immunology, 26(2), 131-139. https://doi.org/10.1016/S0145-305X(01)00055-6