D1-and D2-like receptors differentially mediate the effects of dopaminergic transmission on cost benefit evaluation and motivation in monkeys

Yukiko Hori, Yuji Nagai, Koki Mimura, Tetsuya Suhara, Makoto Higuchi, Sebastien Bouret, Takafumi Minamimoto

研究成果: ジャーナルへの寄稿学術論文査読

7 被引用数 (Scopus)

抄録

It has been widely accepted that dopamine (DA) plays a major role in motivation, yet theAU : Inordertomaintainconsistencythroughoutthearticle; specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit-and costbased motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the bAU : Inordertomaintainconsistencythroughoutthearticle; cost andbenefit basedmotivationhasbeenchangedtobenefit enefit-and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders.

本文言語英語
論文番号e3001055
ジャーナルPLoS Biology
19
7
DOI
出版ステータス出版済み - 07-2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 生化学、遺伝学、分子生物学一般
  • 免疫学および微生物学一般
  • 農業および生物科学一般

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