De novo CD5 + diffuse large B-cell lymphoma: A clinicopathologic study of 109 patients

Motoko Yamaguchi, Masao Seto, Masataka Okamoto, Ryo Ichinohasama, Naoya Nakamura, Tadashi Yoshino, Junji Suzumiya, Takuhei Murase, Ikuo Miura, Takashi Akasaka, Jun Ichi Tamaru, Ritsuro Suzuki, Yoshitoyo Kagami, Masami Hirano, Yasuo Morishima, Ryuzo Ueda, Hiroshi Shiku, Shigeo Nakamura

研究成果: Article査読

239 被引用数 (Scopus)

抄録

De novo CD5 + diffuse large B-cell lymphoma (CD5 + DLBCL) is known to have phenotypically and genotypically different characteristics than CD5 - DLBCL and mantle cell lymphoma (MCL). To further characterize CD5 + DLBCL, 109 patients with CD5 + DLBCL were reviewed, and the results were compared with those of 384 CD5 - DLBCL and 128 cyclin D1 + MCL patients. Patients with CD5 + DLBCL showed a higher age distribution (median, 66 years; P = .0083) and a female predominance (male-female ratio, 49:60, P = .011) compared with those with CD5 - DLBCL. CD5 + DLBCL was more closely associated with many aggressive clinical features or parameters than CD5 - DLBCL: 69% older than 60 years (P = .039), 34% with performance status greater than 1 (P = .0016), 69% with serum lactate dehydrogenase level higher than normal (P < .0001), 62% with stage III/IV disease at diagnosis (P = .0023), 35% with more than one extranodal site (P = .023), and 40% with B symptoms (P = .0031). The overall International Prognostic Index score was thus significantly higher for the patients with CD5 + DLBCL than for those with CD5 - DLBCL (P = .00005). The most frequent site of extranodal involvement was bone marrow (28%), a higher frequency than that for CD5 - DLBCL (P < .0001) but lower than that for cyclin D1 + MCL (P = .0015). Histopathologically, CD5 + DLBCL showed centroblastic morphology except for 3 patients with immunoblastic disease, and interfollicular growth pattern (7%) and intravascular or intrasinusoidal infiltration (19%) were observed. Immunophenotypically, CD5 + DLBCL was characterized by a CD5 +CD10 -CD19 + CD20 +CD21 -CD23 - cyclin D1 - phenotype and a predominance of surface IgMκ. Of particular interest is that CD5 + DLBCL was characterized by a survival curve significantly inferior to that for patients with CD5 - DLBCL (P = .0026). These findings suggest that CD5 + DLBCL may constitute a unique subgroup of DLBCL.

本文言語English
ページ(範囲)815-821
ページ数7
ジャーナルBlood
99
3
DOI
出版ステータスPublished - 01-02-2002

All Science Journal Classification (ASJC) codes

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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