Decreased ADAMTS13 Levels in Patients after Living Donor Liver Transplantation

Toshihiko Kobayashi, Hideo Wada, Masanobu Usui, Hiroyuki Sakurai, Takeshi Matsumoto, Tsutomu Nobori, Naoyuki Katayama, Sinji Uemoto, Hiromichi Ishizashi, Masanori Matsumoto, Yoshihiro Fujimura, Shuji Isaji

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Introduction: Thrombotic microangiopathy (TMA) is a complication occurring after liver transplantation (LT), and an unusually large multimer (ULM) of Von Willebrand factor (VWF) and ADAMTS13 may play an important role in the onset of TMA during LT. Material and Methods: Eight-one patients underwent living donor LT (LDLT). Seventeen of those patients had both severe thrombocytopenia and hemolytic anemia with fragmented red cells and were diagnosed as TMA- like syndrome (TMALS). Results and Conclusions: A significant reduction of ADAMTS13 and an increase of VWF were observed in the patients with TMALS. The ADAMTS13 activity in patients after LDLT was significantly reduced from day 1 to day 21, and it was significantly low in those with TMALS at day 14 and 28. The VWF levels in patients with LDLT were significantly high, and the VWF/ADAMTS13 ratio was significantly increased in patients at 7, 14 and 28 days after LDLT, especially in patients with TMALS at day 14 and 28 after LDLT. High molecular weight multimers of VWF were observed to have increased in patients with LDLT, and the high molecular weight multimers of VWF were further increased in those with mild TMALS but they decreased in those with severe TMA. These findings suggest that ULM- VWF and ADAMTS13 might be associated with the onset of TMA after LT.

本文言語English
ページ(範囲)541-545
ページ数5
ジャーナルThrombosis Research
124
5
DOI
出版ステータスPublished - 11-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Hematology

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