Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia

Kiyofumi Yamada, Kazuhiko Kono, Hiroyuki Umegaki, Kazuyoshi Yamada, Akihisa Iguchi, Toshiaki Fukatsu, Nobou Nakashima, Hirotshi Nishiwaki, Yasuhiro Shimada, Yasuko Sugita, Takayuki Yamamoto, Takaaki Hasegawa, Toshitaka Nabeshima

研究成果: Article

54 引用 (Scopus)

抜粋

We examined IL-6 levels in the cerebrospinal fluid (CSF) of patients clinically diagnosed with Alzheimer-type dementia (ATD) and with vascular dementia (VD) and of age-matched normal subjects. The IL-6 levels in the CSF of ATD, but not VD patients, were significantly decreased. In the early onset ATD patients (disease onset <65 years), IL-6 levels were reduced to 21% of the control level. The IL-6 levels in the CSF were not associated with the severity of the dementia or the duration of the disease since the identification of the first symptoms.

元の言語English
ページ(範囲)219-221
ページ数3
ジャーナルNeuroscience Letters
186
発行部数2-3
DOI
出版物ステータスPublished - 17-02-1995
外部発表Yes

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Yamada, K., Kono, K., Umegaki, H., Yamada, K., Iguchi, A., Fukatsu, T., Nakashima, N., Nishiwaki, H., Shimada, Y., Sugita, Y., Yamamoto, T., Hasegawa, T., & Nabeshima, T. (1995). Decreased interleukin-6 level in the cerebrospinal fluid of patients with Alzheimer-type dementia. Neuroscience Letters, 186(2-3), 219-221. https://doi.org/10.1016/0304-3940(95)11318-Q