Decreased l-tryptophan concentration in distinctive brain regions of mice treated repeatedly with phencyclidine Amino Acid Analysis

Hideaki Iizuka, Shoko Watanabe, Mayuko Koshikawa, Yurie Matsumoto, Yuki Aoyama, Hideaki Ichiba, Toshitaka Nabeshima, Takeshi Fukushima

研究成果: Article査読

3 被引用数 (Scopus)

抄録

It has been reported that repeated phencyclidine (PCP) treatment induces schizophrenia-like behavior in mice. l-Tryptophan (Trp) concentrations in brain tissues of control (n = 8) and PCP-treated mice (10 mg/kg/day, s.c., 14 days, n = 10) were determined using high-performance liquid chromatography (HPLC) with fluorescence detection. The HPLC method involved pre-column fluorescence derivatization with (R)-(-)-4-(N,N-dimethylaminosulfonyl)-7-(3- isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole (DBD-PyNCS). Eight different parts of the brain, namely, the frontal cortex, nucleus accumbens, striatum, hippocampus, amygdala, thalamus, hypothalamus, and cerebellum, of both groups were investigated. A significant decrease in the l-Trp concentration in the nucleus accumbens (p = 0.024) and hippocampus (p = 0.027) was observed in PCP-treated mice, suggesting that alteration of the l-Trp metabolism might occur in these brain parts.

本文言語English
ページ(範囲)8137-8141
ページ数5
ジャーナルAnalytical and Bioanalytical Chemistry
405
25
DOI
出版ステータスPublished - 10-2013

All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学

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