Degradation of human Aurora-A protein kinase is mediated by hCdh1

Sei ichi Taguchi, Kei Honda, Kazumitsu Sugiura, Akio Yamaguchi, Koichi Furukawa, Takeshi Urano

研究成果: Article

77 引用 (Scopus)

抜粋

Human Aurora-A is related to a protein kinase originally identified by its close homology to Ipl1p from Saccharomyces cerevisiae and aurora from Drosophila melanogaster, which are key regulators of the structure and function of the mitotic spindle. We previously showed that human Aurora-A is turned over through the anaphase promoting complex/cyclosome (APC/C)-ubiquitin-proteasome pathway. The association of two distinct WD40 repeat proteins known as Cdc20 and Cdh1, respectively, sequentially activates the APC/C. The present study shows that Aurora-A degradation is dependent on hCdh1 in vivo, not on hCdc20, and that Aurora-A is targeted for proteolysis through distinct structural features of the destruction box, the KEN box motifs and its kinase activity.

元の言語English
ページ(範囲)59-65
ページ数7
ジャーナルFEBS Letters
519
発行部数1-3
DOI
出版物ステータスPublished - 22-05-2002
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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  • これを引用

    Taguchi, S. I., Honda, K., Sugiura, K., Yamaguchi, A., Furukawa, K., & Urano, T. (2002). Degradation of human Aurora-A protein kinase is mediated by hCdh1. FEBS Letters, 519(1-3), 59-65. https://doi.org/10.1016/S0014-5793(02)02711-4