Depressive symptoms of female nursing staff working in stressful environments and their association with serum creatine kinase and lactate dehydrogenase - a preliminary study

Ayako Kato, Hiroyuki Sakakibara, Hirohito Tsuboi, Asami Tatsumi, Masanobu Akimoto, Kayoko Shimoi, Takeshi Ishii, Hiroshi Kaneko, Tsutomu Nakayama, Norio Ohashi

研究成果: ジャーナルへの寄稿学術論文査読

8 被引用数 (Scopus)

抄録

Background: The activity of creatine kinase (CK) in serum has recently been reported to be potentially associated with several types of depression. The aim of this study is to evaluate whether serum enzymes, including CK, vary even in a healthy population with depressive symptoms caused by work-related stress. We gave questionnaires and blood examinations to 93 healthy female nursing home workers and did an enzyme-linked immunosorbent assay for the quantitative detection of CK isozyme muscle-type M chain (CK-MM) in serum.Findings: Depressive symptoms were determined using the Center for Epidemiologic Studies Depression (CES-D) scale and compared with the results of the blood examination and serum CK-MM levels. The CES-D results showed significant negative correlations with total CK and lactate dehydrogenase (LDH) activities and CK-MM level (r = -0.29, p = 0.0062; r = -0.29, p = 0.0065; r = -0.33, p = 0.0016, respectively).Conclusions: Total CK and LDH activities and serum CK-MM level appear to be associated with the depressive symptoms of healthy nurses working in stressful environments, although the significance level was relatively low. The simultaneous detection of serum CK and LDH activities or serum CK-MM level and LDH activity may be useful as an indicator of depressive symptoms, at least for female nursing staff with work-related stress.

本文言語英語
論文番号21
ジャーナルBioPsychoSocial Medicine
8
1
DOI
出版ステータス出版済み - 09-09-2014
外部発表はい

All Science Journal Classification (ASJC) codes

  • 社会心理学
  • 心理学一般
  • 精神医学および精神衛生
  • 生物学的精神医学

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