TY - JOUR
T1 - Deregulated transcription factors in leukemia
AU - Shima, Yutaka
AU - Kitabayashi, Issay
PY - 2011/8
Y1 - 2011/8
N2 - Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBPα, RARα, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal proliferation and/or survival. This review focuses on such transcription factors and coactivators, and describes their roles in leukemogenesis and hematopoiesis.
AB - Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBPα, RARα, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal proliferation and/or survival. This review focuses on such transcription factors and coactivators, and describes their roles in leukemogenesis and hematopoiesis.
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U2 - 10.1007/s12185-011-0905-9
DO - 10.1007/s12185-011-0905-9
M3 - Review article
C2 - 21823042
AN - SCOPUS:80052384568
SN - 0925-5710
VL - 94
SP - 134
EP - 141
JO - International Journal of Hematology
JF - International Journal of Hematology
IS - 2
ER -