Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

Hiromasa Kurosaki; Hisami Yasuzawa; Yoshihiro Yamaguchi; Wanchun Jin; Yoshichika Arakawa; Masafumi Goto

doi:10.1039/b209086d

Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

Hiromasa Kurosaki, Hisami Yasuzawa, Yoshihiro Yamaguchi, Wanchun Jin, Yoshichika Arakawa, Masafumi Goto

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

18 被引用数 (Scopus)

抄録

A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3-mercaptopropionamide (Dansyl-C2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.

本文言語	英語
ページ（範囲）	17-20
ページ数	4
ジャーナル	Organic and Biomolecular Chemistry
巻	1
号	1
DOI	https://doi.org/10.1039/b209086d
出版ステータス	出版済み - 07-01-2003
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
物理化学および理論化学
有機化学

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10.1039/b209086d

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author = "Hiromasa Kurosaki and Hisami Yasuzawa and Yoshihiro Yamaguchi and Wanchun Jin and Yoshichika Arakawa and Masafumi Goto",

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doi = "10.1039/b209086d",

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AU - Kurosaki, Hiromasa

AU - Yasuzawa, Hisami

AU - Yamaguchi, Yoshihiro

AU - Jin, Wanchun

AU - Arakawa, Yoshichika

AU - Goto, Masafumi

PY - 2003/1/7

Y1 - 2003/1/7

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AB - A fluorescent probe for the detection of a metallo-β-lactamase (IMP-1), N-[2-(5-dimethylaminonaphthalen-1-ylsulfonylamino)ethyl]-3-mercaptopropionamide (Dansyl-C2SH), 1, was designed based on combining the inhibitory function of mercaptocarboxylate and a fluorophore. The binding of 1 to IMP-1 was investigated by fluorescence spectroscopy. Compound 1 can act as fluorescent probe for detecting IMP-1 selectively.

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Detection of a metallo-β-lactamase (IMP-1) by fluorescent probes having dansyl and thiol groups

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