Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-α: 3′,2′-d]imidazole (Glu-P-1) in Glu-P-1-injected rats

Yoshikatsu Kanai; Shigeo Manabe; Osamu Wada

doi:10.1016/0165-7992(88)90043-7

Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-α: 3′,2′-d]imidazole (Glu-P-1) in Glu-P-1-injected rats

Yoshikatsu Kanai
, Shigeo Manabe
, Osamu Wada

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

2 被引用数 (Scopus)

抄録

In order to confirm in vivo N-acetylation of 2-amino-6-methyl-dipyrido[1,2-a:3′,2′-d]imidazole (GluP-1) in rats, we developed a new high-performance liquid chromatography (HPLC) method for detecting the N-acetyl derivative of Glu-P-1 in animal organs. Using this method, N-acetyl-Glu-P-1 was detected in rat liver, kidney and intestinal contents 6 h after intraperitoneal injection of Glu-P-1. This fact provides evidence to support in vivo N-acetylation of Glu-P-1 in rats.

本文言語	英語
ページ（範囲）	63-67
ページ数	5
ジャーナル	Mutation Research Letters
巻	207
号	2
DOI	https://doi.org/10.1016/0165-7992(88)90043-7
出版ステータス	出版済み - 02-1988
外部発表	はい

All Science Journal Classification (ASJC) codes

医学一般

文献へのアクセス

10.1016/0165-7992(88)90043-7

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「Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-α: 3′,2′-d]imidazole (Glu-P-1) in Glu-P-1-injected rats」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

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title = "Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-α: 3′,2′-d]imidazole (Glu-P-1) in Glu-P-1-injected rats",

abstract = "In order to confirm in vivo N-acetylation of 2-amino-6-methyl-dipyrido[1,2-a:3′,2′-d]imidazole (GluP-1) in rats, we developed a new high-performance liquid chromatography (HPLC) method for detecting the N-acetyl derivative of Glu-P-1 in animal organs. Using this method, N-acetyl-Glu-P-1 was detected in rat liver, kidney and intestinal contents 6 h after intraperitoneal injection of Glu-P-1. This fact provides evidence to support in vivo N-acetylation of Glu-P-1 in rats.",

keywords = "(Rat), Glu-P-1, In vivo, N-Acetylation",

author = "Yoshikatsu Kanai and Shigeo Manabe and Osamu Wada",

year = "1988",

month = feb,

doi = "10.1016/0165-7992(88)90043-7",

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TY - JOUR

T1 - Detection of N-acetyl derivative of 2-amino-6-methyldipyrido[1,2-α

T2 - 3′,2′-d]imidazole (Glu-P-1) in Glu-P-1-injected rats

AU - Kanai, Yoshikatsu

AU - Manabe, Shigeo

AU - Wada, Osamu

PY - 1988/2

Y1 - 1988/2

N2 - In order to confirm in vivo N-acetylation of 2-amino-6-methyl-dipyrido[1,2-a:3′,2′-d]imidazole (GluP-1) in rats, we developed a new high-performance liquid chromatography (HPLC) method for detecting the N-acetyl derivative of Glu-P-1 in animal organs. Using this method, N-acetyl-Glu-P-1 was detected in rat liver, kidney and intestinal contents 6 h after intraperitoneal injection of Glu-P-1. This fact provides evidence to support in vivo N-acetylation of Glu-P-1 in rats.

AB - In order to confirm in vivo N-acetylation of 2-amino-6-methyl-dipyrido[1,2-a:3′,2′-d]imidazole (GluP-1) in rats, we developed a new high-performance liquid chromatography (HPLC) method for detecting the N-acetyl derivative of Glu-P-1 in animal organs. Using this method, N-acetyl-Glu-P-1 was detected in rat liver, kidney and intestinal contents 6 h after intraperitoneal injection of Glu-P-1. This fact provides evidence to support in vivo N-acetylation of Glu-P-1 in rats.

KW - (Rat)

KW - Glu-P-1

KW - In vivo

KW - N-Acetylation

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U2 - 10.1016/0165-7992(88)90043-7

DO - 10.1016/0165-7992(88)90043-7

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AN - SCOPUS:0023902320

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JF - Mutation Research Letters

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