Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on sitespecific pharmacokinetic-pharmacodynamic evaluation

Kogenta Nakamura, Kazuro Ikawa, Yoshiaki Yamada, Maki Arakawa, Kenji Zennami, Genya Nishikawa, Kayo Ikeda, Norifumi Morikawa, Nobuaki Honda

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Prostatic hypertrophy patients prophylactically received a 0.5-hour infusion of doripenem (250 or 500 mg) before transurethral resection of the prostate. Doripenem concentrations in plasma and prostate tissue were measured chromatographically, and analysed pharmacokinetically using a three-compartment model. The approved doripenem regimens were assessed based on the time above the minimum inhibitory concentration for bacteria (T>MIC, % of 24 hours), an indicator for antibacterial effects, at the prostate. The prostate tissue/plasma ratios were 17.3% for the maximum drug concentration and 18.7% for the area under the drug concentration-time curve, and they were irrespective of the dose. Against Escherichia coli and Klebsiella species isolates, 500 mg once daily achieved a>90% probability of attaining the bacteriostatic target (20% T>MIC) in prostate tissue, and 500 mg twice daily achieved a>90% probability of attaining the bactericidal target (40% T>MIC) in prostate tissue.

本文言語English
ページ(範囲)32-37
ページ数6
ジャーナルJournal of Chemotherapy
24
1
DOI
出版ステータスPublished - 01-02-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 薬理学
  • 薬理学(医学)
  • 感染症

フィンガープリント

「Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on sitespecific pharmacokinetic-pharmacodynamic evaluation」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル