Development of a method for automated and stable myocardial perfusion measurement using coronary X-ray angiography images

Takuya Sakaguchi, Takashi Ichihara, Takahiro Natsume, Jingwu Yao, Omair Yousuf, Jeffrey C. Trost, Joao A.C. Lima, Richard T. George

研究成果: ジャーナルへの寄稿学術論文査読

6 被引用数 (Scopus)

抄録

The purpose of this study was to develop a method for automatic and stable determination of the optimal time range for fitting with a Patlak plot model in order to measure myocardial perfusion using coronary X-ray angiography images. A conventional two-compartment model is used to measure perfusion, and the slope of the Patlak plot is calculated to obtain a perfusion image. The model holds for only a few seconds while the contrast agent flows from artery to myocardium. Therefore, a specific time range should be determined for fitting with the model. To determine this time range, automation is needed for routine examinations. The optimal time range was determined to minimize the standard error between data points and their least-squares regression straight line in the Patlak plot. A total of 28 datasets were tested in seven porcine models. The new method successfully detected the time range when contrast agent flowed from artery to myocardium. The mean cross correlation in the linear regression analysis (R2) was 0.996 ± 0.004. The mean length of the optimal time range was 3.61 ± 1.29 frames (2.18 ± 1.40 s). This newly developed method can automatically determine the optimal time range for fitting with the model.

本文言語英語
ページ(範囲)905-914
ページ数10
ジャーナルInternational Journal of Cardiovascular Imaging
31
5
DOI
出版ステータス出版済み - 29-06-2015

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング
  • 循環器および心血管医学

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