Diabetes with Preserved Renal Function Is an Independent Risk Factor for Renal Function Deterioration after Coronary Computed Tomography Angiography

Satoshi Isobe, Takashi Yamada, Kimihide Sato, Toshio Katagiri, Hisato Ohyama, Mutsuharu Hayashi, Daiji Yoshikawa, Hideki Ishii, Toyoaki Murohara

研究成果: Article査読

8 被引用数 (Scopus)

抄録

OBJECTIVES: Diabetes mellitus (DM) and high fasting glucose levels are reportedly risk factors for contrast-induced nephropathy after invasive coronary angiography in patients with renal dysfunction. Cystatin C (CyC) is a sensitive marker for detecting early impairment of renal function. Using CyC, we investigated whether DM would be a risk for worsening renal function after coronary computed tomography angiography (CCTA) in patients with preserved renal function. METHODS: Two hundred twenty-eight patients scheduled for CCTA were enrolled. The serum CyC at preprocedure and 1 day after procedure, urinary microalbumin at preprocedure, and oral fluid volume for 24 hours after procedure were measured. The percentage changes in CyC from preprocedure to 1 day after procedure (%CyC) were also calculated. RESULTS: Ninety-eight patients had DM. The %CyC and urinary microalbumin were significantly greater in DM patients than in non-DM patients. The percentage of patients showing a %CyC of 10% or greater was significantly greater in DM patients than in non-DM patients (27% vs 8%, P < 0.01). Using multivariate regression analysis, oral fluid volume and urinary microalbumin were independent predictors for a %CyC of 10% or greater in DM patients (β =-0.428 [P < 0.0001] and β = 0.464 [P < 0.0001], respectively). CONCLUSIONS: Diabetes mellitus is a risk factor for worsening changes in renal function after CCTA, even in patients with preserved renal function. In particular, elevated microalbuminuria and low oral fluid intake are high-risk factors for renal functional deterioration.

本文言語English
ページ(範囲)750-754
ページ数5
ジャーナルJournal of Computer Assisted Tomography
37
5
DOI
出版ステータスPublished - 09-2013
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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