Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies

Shigehisa Kajikawa, Naoyuki Imai, Shotaro Okachi, Hiroshi Yatsuya, Tomohide Souma, Toshikazu Watanabe, Yasuhiro Goto, Tomoyuki Minezawa, Naozumi Hashimoto, Kazuyoshi Imaizumi, Yoshinori Hasegawa

研究成果: Article

抄録

Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

元の言語English
ページ(範囲)613-620
ページ数8
ジャーナルNagoya journal of medical science
81
発行部数4
DOI
出版物ステータスPublished - 01-01-2019

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Biopsy
Lung
Neoplasms
Cell Biology
Surgical Instruments
Medical Records

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Kajikawa, Shigehisa ; Imai, Naoyuki ; Okachi, Shotaro ; Yatsuya, Hiroshi ; Souma, Tomohide ; Watanabe, Toshikazu ; Goto, Yasuhiro ; Minezawa, Tomoyuki ; Hashimoto, Naozumi ; Imaizumi, Kazuyoshi ; Hasegawa, Yoshinori. / Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies. :: Nagoya journal of medical science. 2019 ; 巻 81, 番号 4. pp. 613-620.
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title = "Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies",
abstract = "Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3{\%}, CTBB: 66.0{\%}). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1{\%} (17/137), compared with only 4.1{\%} (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7{\%} (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.",
author = "Shigehisa Kajikawa and Naoyuki Imai and Shotaro Okachi and Hiroshi Yatsuya and Tomohide Souma and Toshikazu Watanabe and Yasuhiro Goto and Tomoyuki Minezawa and Naozumi Hashimoto and Kazuyoshi Imaizumi and Yoshinori Hasegawa",
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Kajikawa, S, Imai, N, Okachi, S, Yatsuya, H, Souma, T, Watanabe, T, Goto, Y, Minezawa, T, Hashimoto, N, Imaizumi, K & Hasegawa, Y 2019, 'Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies', Nagoya journal of medical science, 巻. 81, 番号 4, pp. 613-620. https://doi.org/10.18999/nagjms.81.4.613

Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies. / Kajikawa, Shigehisa; Imai, Naoyuki; Okachi, Shotaro; Yatsuya, Hiroshi; Souma, Tomohide; Watanabe, Toshikazu; Goto, Yasuhiro; Minezawa, Tomoyuki; Hashimoto, Naozumi; Imaizumi, Kazuyoshi; Hasegawa, Yoshinori.

:: Nagoya journal of medical science, 巻 81, 番号 4, 01.01.2019, p. 613-620.

研究成果: Article

TY - JOUR

T1 - Diagnostic contribution of cytological examination to endobronchial ultrasound-guided transbronchial biopsy for lung malignancies

AU - Kajikawa, Shigehisa

AU - Imai, Naoyuki

AU - Okachi, Shotaro

AU - Yatsuya, Hiroshi

AU - Souma, Tomohide

AU - Watanabe, Toshikazu

AU - Goto, Yasuhiro

AU - Minezawa, Tomoyuki

AU - Hashimoto, Naozumi

AU - Imaizumi, Kazuyoshi

AU - Hasegawa, Yoshinori

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

AB - Although endobronchial ultrasound guided transbronchial biopsy (TBB) with a guide sheath (EBUSGS) is widely used for diagnosis of peripheral pulmonary lesions, the diagnostic contribution of cytology (bronchial brushing, bronchial washing and biopsy forceps rinse) has not been established. To determine the diagnostic contribution of cytological examination to EBUS-GS-TBB, we reviewed medical records of patients with lung malignancies who had undergone TBB with EBUS-GS (EBUS-GS group, n=187) or TBB without EBUS-GS (conventional TBB [CTBB] group, n=197) at Nagoya University Hospital. Although the mean size of target lesions was significantly larger in the CTBB group than the EBUS-GS group, the total diagnostic rate was equivalent between two groups (EBUS-GS: 73.3%, CTBB: 66.0%). In the EBUS-GS group, cytological procedures increased the diagnostic rate by 9.1% (17/137), compared with only 4.1% (8/130) in the CTBB group. Sensitivity of cytology among biopsy-negative patients was significantly higher in EBUS-GS group than CTBB group (P=0.022). Furthermore, in the EBUS-GS group, among 17 patients whose malignant diagnoses could only be established cytologically, bronchial brushing contributed to the malignant diagnosis in 64.7% (11/17). These data may suggest that cytological examination, especially bronchial brushing, may be an important diagnostic contributor in EBUS-GS-TBB.

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