Dietary Aloe Vera gel powder and extract inhibit azoxymethaneinduced colorectal aberrant crypt foci in mice fed a highfat diet

Takeshi Chihara, Kan Shimpo, Takaaki Kaneko, Hidehiko Beppu, Takashi Higashiguchi, Shigeru Sonoda, Miyuki Tanaka, Muneo Yamada, Fumiaki Abe

研究成果: ジャーナルへの寄稿学術論文査読

4 被引用数 (Scopus)

抄録

Aloe vera gel exhibits protective effects against insulin resistance as well as lipid-lowering and anti-diabetic effects. The anti-diabetic compounds in this gel were identified as Aloe-sterols. Aloe vera gel extract (AVGE) containing Aloe-sterols has recently been produced using a new procedure. We previously reported that AVGE reduced large-sized intestinal polyps in Apc-deficient Min mice fed a high fat diet (HFD), suggesting that Aloe vera gel may protect against colorectal cancer. In the present study, we examined the effects of Aloe vera gel powder (AVGP) and AVGE on azoxymethane-induced colorectal preneoplastic aberrant crypt foci (ACF) in mice fed a HFD. Male C57BL/6J mice were given a normal diet (ND), HFD, HFD containing 0.5% carboxymethyl cellulose solution, which was used as a solvent for AVGE (HFDC), HFD containing 3% or 1% AVGP, and HFDC containing 0.0125% (H-) or 0.00375% (L-) AVGE. The number of ACF was significantly lower in mice given 3% AVGP and H-AVGE than in those given HFD or HFDC alone. Moreover, 3% AVGP, H-AVGE and L-AVGE significantly decreased the mean Ki-67 labeling index, assessed as a measure of cell proliferation in the colonic mucosa. In addition, hepatic phase II enzyme glutathione S-transferase mRNA levels were higher in the H-AVGE group than in the HFDC group. These results suggest that both AVGP and AVGE may have chemopreventive effects on colorectal carcinogenesis under the HFD condition. Furthermore, the concentration of Aloe-sterols was similar between 3% AVGP and H-AVGE, suggesting that Aloe-sterols were the main active ingredients in this experiment.

本文言語英語
ページ(範囲)683-687
ページ数5
ジャーナルAsian Pacific Journal of Cancer Prevention
16
2
DOI
出版ステータス出版済み - 2015

All Science Journal Classification (ASJC) codes

  • 疫学
  • 腫瘍学
  • 公衆衛生学、環境および労働衛生
  • 癌研究

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