Differences in urinary arsenic metabolites between diabetic and non-diabetic subjects in Bangladesh

Saika Nizam, Masashi Kato, Hiroshi Yatsuya, Md Khalequzzaman, Shoko Ohnuma, Hisao Naito, Tamie Nakajima

研究成果: Article査読

32 被引用数 (Scopus)

抄録

Ingestion of inorganic arsenic (iAs) is considered to be related to the development of diabetes mellitus. In order to clarify the possible differences in the metabolism in diabetics, we measured urinary iAs metabolites in diabetic cases and non-diabetic control subjects in Faridpur, an arsenic-contaminated area in Bangladesh. Physician-diagnosed type 2 diabetic cases (140 persons) and non-diabetic controls (180 persons) were recruited. Drinking water and spot urine samples were collected. Mean concentrations of total arsenic in drinking water did not differ between cases (85.1 μg/L) and controls (85.8 μg/L). The percentage of urinary iAs (iAs%) was significantly lower in cases (8.6%) than in controls (10.4%), while that of dimethylarsinic acid (DMA%) was higher in cases (82.6%) than in controls (79.9%). This may have been due to the higher secondary methylation index (SMI) in the former (11.6) rather than the latter (10.0). Adjusting for matching factors (sex and unions), and the additional other covariates (age and water arsenic) significantly attenuated the differences in iAs%, SMI, and DMA%, respectively, though the difference in monomethylarsonic acid% was newly significant in the latter adjustment. Our study did not suggest any significant differences in urinary arsenic metabolites between diabetic and non-diabetic subjects.

本文言語English
ページ(範囲)1006-1019
ページ数14
ジャーナルInternational Journal of Environmental Research and Public Health
10
3
DOI
出版ステータスPublished - 03-2013

All Science Journal Classification (ASJC) codes

  • 汚染
  • 公衆衛生学、環境および労働衛生
  • 健康、毒物学および変異誘発

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