TY - JOUR
T1 - Different effects of ethylketocyclazocine on phencyclidine- and N-allylnormetazocine-induced stereotyped behaviors in rats
AU - Hiramatsu, Masayuki
AU - Nabeshima, Toshitaka
AU - Furukawa, Hiroshi
AU - Kameyama, Tsutomu
N1 - Funding Information:
This study was supported in part by grants-in-aid from The Research Foundation for Pharmaceutical Sciences (No. 59-1-12), 1986 Incentive Award of the Pharmaceutical Society of Japan and The Science Research Promotion Fund of Japan Private School Promotion Foundation (No. 1986-11). We thank Dr. K. Yamaguchi, Nihon Bioresearch Center Inc. for the supply of animals and thank Miss N. Ito and Y. Maeda for their technical supports. We also thank Mr. W. Petruschak for the English revision of the manuscript. Ethylketocyclazocine and SKF 10,047 were generously supplied by Sterling Winthrop and NIDA, respectively.
PY - 1987/12
Y1 - 1987/12
N2 - The effects of ethylketocyclazocine (EKC) on the stereotyped behaviors induced by intraperitoneal injection of phencyclidine (PCP) or N-allylnormetazocine (SKF 10,047) were examined. EKC markedly antagonized PCP-induced stereotyped behaviors such as sniffing, head-weaving, turning and backpedalling. On the other hand, EKC failed to antagonize SKF 10,047-induced stereotyped behaviors, which are PCP-like stereotyped behaviors, except sniffing and head-weaving at 0-15 min after the SKF 10,047 injection. PCP-induced turning and backpedalling were potentiated by pretreatment with SKF 10,047, while PCP-induced sniffing and head-weaving were not. EKC failed to affect the enhancing effect of SKF 10,047 on PCP-induced turning and backpedalling. These results suggest that part of the PCP- and SKF 10,047-induced stereotypy may be mediated by different neuronal mechanisms.
AB - The effects of ethylketocyclazocine (EKC) on the stereotyped behaviors induced by intraperitoneal injection of phencyclidine (PCP) or N-allylnormetazocine (SKF 10,047) were examined. EKC markedly antagonized PCP-induced stereotyped behaviors such as sniffing, head-weaving, turning and backpedalling. On the other hand, EKC failed to antagonize SKF 10,047-induced stereotyped behaviors, which are PCP-like stereotyped behaviors, except sniffing and head-weaving at 0-15 min after the SKF 10,047 injection. PCP-induced turning and backpedalling were potentiated by pretreatment with SKF 10,047, while PCP-induced sniffing and head-weaving were not. EKC failed to affect the enhancing effect of SKF 10,047 on PCP-induced turning and backpedalling. These results suggest that part of the PCP- and SKF 10,047-induced stereotypy may be mediated by different neuronal mechanisms.
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U2 - 10.1016/0091-3057(87)90511-9
DO - 10.1016/0091-3057(87)90511-9
M3 - Article
C2 - 2893389
AN - SCOPUS:0023514319
SN - 0091-3057
VL - 28
SP - 489
EP - 494
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 4
ER -