TY - JOUR
T1 - Different timing and risk factors of cause-specific pancreas graft loss after simultaneous pancreas kidney transplantation
AU - Tomimaru, Yoshito
AU - Kobayashi, Shogo
AU - Ito, Toshinori
AU - Sasaki, Kazuki
AU - Iwagami, Yoshifumi
AU - Yamada, Daisaku
AU - Noda, Takehiro
AU - Takahashi, Hidenori
AU - Kenmochi, Takashi
AU - Doki, Yuichiro
AU - Eguchi, Hidetoshi
N1 - Funding Information:
We thank Dr. Masaaki Watanabe and Dr. Yasuyuki Koshizuka (Hokkaido University Hospital), Dr Shigehito Miyagi and Dr. Kazuaki Tokodai (Tohoku University Hospital), Dr. Ryo Okada and Dr. Akira Kenjo (Fukushima Medical University Hospital), Dr. Yukihiro Iso and Dr. Keiichi Kubota (Dokkyo Medical University Hospital), Dr. Hiroto Egawa and Dr. Yoshihito Kotera (Tokyo Women’s Medical University Hospital), Dr. Shigeyuki Kawachi and Dr. Hitoshi Iwamoto (Tokyo Medical University Hachioji Medical Center), Dr. Toshifumi Wakai and Dr. Takashi Kobayashi (Niigata University Hospital), Dr. Shunji Narumi and Dr. Takahisa Hiramitsu (Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital), Dr. Taihei Ito (Fujita Health University Hospital), Dr. Hidetaka Ushigome and Dr. Shuji Nobori (Kyoto Prefectural University Hospital), Dr. Takayuki Anazawa and Dr. Hideaki Okajima (Kyoto University Hospital), Dr. Hirochika Toyama and Dr. Yoshihide Nanno (Kobe University Hospital), Dr. Hideki Ohdan and Dr. Hiroyuki Tahara (Hiroshima University Hospital), Dr. Keiichi Okano and Dr. Minoru Oshima (Kagawa University Hospital), Dr. Keizo Kaku and Dr. Yasuhiro Okabe (Kyushu University Hospital), Dr. Tomohiko Adachi and Dr. Hajime Matsushima (Nagasaki University Hospital), and Dr. Yoshifumi Beck and Dr. Akira Maki (Saitama Medical Center, Saitama Medical University) for their cooperation with the Japan Pancreas Transplant Registry of The Japanese Pancreas and Islet Transplant Association.
Publisher Copyright:
© 2022, The Author(s).
PY - 2022/12
Y1 - 2022/12
N2 - In cases after pancreas transplantation (PTx), the pancreas graft might be lost for various reasons, including a pancreatoduodenal graft-related complication or patient death with a functioning graft. Although the causes seem to have distinct characteristics, the causes of pancreas graft loss have not been characterized. This study aimed to characterize the causes of pancreas graft loss by analyzing data from a Japanese nationwide registry. This study included 391 patients who received simultaneous pancreas-kidney transplantation among 461 patients with PTx during the study period in approved institutions in Japan. We characterized each cause in terms of the timing of the cause-specific graft loss and preoperative factors associated with graft loss based on nationwide data from a Japanese nationwide registry. Among the 391 cases, 113 lost the pancreas graft due to patient death with a functioning graft (DWFG; n = 34, 44.2%), graft thrombus (n = 22, 28.6%), or chronic rejection (CR; n = 7, 9.1%). Average (± standard deviation) time from PTx to graft loss due to DWFG, graft thrombus, and CR was 3.70 ± 4.36, 0.02 ± 0.01, and 2.37 ± 2.08 years, respectively. Duration of type 1 diabetes mellitus and donor body mass index were significantly associated with pancreas graft loss due to DWFG and graft thrombus, respectively. This characterization showed that the timing and preoperative factors associated with pancreas graft loss were significantly different for different causes of graft loss. These results may inform PTx follow-up protocols to ensure that appropriate care is based on the cause of graft loss.
AB - In cases after pancreas transplantation (PTx), the pancreas graft might be lost for various reasons, including a pancreatoduodenal graft-related complication or patient death with a functioning graft. Although the causes seem to have distinct characteristics, the causes of pancreas graft loss have not been characterized. This study aimed to characterize the causes of pancreas graft loss by analyzing data from a Japanese nationwide registry. This study included 391 patients who received simultaneous pancreas-kidney transplantation among 461 patients with PTx during the study period in approved institutions in Japan. We characterized each cause in terms of the timing of the cause-specific graft loss and preoperative factors associated with graft loss based on nationwide data from a Japanese nationwide registry. Among the 391 cases, 113 lost the pancreas graft due to patient death with a functioning graft (DWFG; n = 34, 44.2%), graft thrombus (n = 22, 28.6%), or chronic rejection (CR; n = 7, 9.1%). Average (± standard deviation) time from PTx to graft loss due to DWFG, graft thrombus, and CR was 3.70 ± 4.36, 0.02 ± 0.01, and 2.37 ± 2.08 years, respectively. Duration of type 1 diabetes mellitus and donor body mass index were significantly associated with pancreas graft loss due to DWFG and graft thrombus, respectively. This characterization showed that the timing and preoperative factors associated with pancreas graft loss were significantly different for different causes of graft loss. These results may inform PTx follow-up protocols to ensure that appropriate care is based on the cause of graft loss.
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U2 - 10.1038/s41598-022-22321-x
DO - 10.1038/s41598-022-22321-x
M3 - Article
C2 - 36271021
AN - SCOPUS:85140293390
VL - 12
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 17666
ER -