Differential expression of plexin-A subfamily members in the mouse nervous system

Yasunori Murakami, Fumikazu Suto, Masayuki Shimizu, Tomoyasu Shinoda, Toshiki Kameyama, Hajime Fujisawa

研究成果: Article

91 引用 (Scopus)

抄録

Plexins comprise a family of transmembrane proteins (the plexin family) which are expressed in nervous tissues. Some plexins have been shown to interact directly with secreted or transmembrane semaphorins, while plexins belonging to the A subfamily are suggested to make complexes with other membrane proteins, neuropilins, and propagate chemorepulsive signals of secreted semaphorins of class 3 into cells or neurons. Despite that much information has been gathered on the plexin-semaphorin interaction, the role of plexins in the nervous system is not well understood. To gain insight into the functions of plexins in the nervous system, we analyzed spatial and temporal expression patterns of three members of the plexin-A subfamily (plexin-A1, -A2, and -A3) in the developing mouse nervous system by in situ hybridization analysis in combination with immunohistochemistry. We show that the three plexins are differentially expressed in sensory receptors or neurons in a developmentally regulated manner, suggesting that a particular plexin or set of plexins is shared by neuronal elements and functions as the receptor for semaphorins to regulate neuronal development.

元の言語English
ページ(範囲)246-258
ページ数13
ジャーナルDevelopmental Dynamics
220
発行部数3
DOI
出版物ステータスPublished - 06-03-2001

Fingerprint

Semaphorins
Nervous System
Sensory Receptor Cells
Neuropilins
Nerve Tissue
varespladib methyl
In Situ Hybridization
Membrane Proteins
Immunohistochemistry
plexin
Neurons
Proteins

All Science Journal Classification (ASJC) codes

  • Developmental Biology

これを引用

Murakami, Yasunori ; Suto, Fumikazu ; Shimizu, Masayuki ; Shinoda, Tomoyasu ; Kameyama, Toshiki ; Fujisawa, Hajime. / Differential expression of plexin-A subfamily members in the mouse nervous system. :: Developmental Dynamics. 2001 ; 巻 220, 番号 3. pp. 246-258.
@article{da1d017b62bc46a5a4a171383753e0c8,
title = "Differential expression of plexin-A subfamily members in the mouse nervous system",
abstract = "Plexins comprise a family of transmembrane proteins (the plexin family) which are expressed in nervous tissues. Some plexins have been shown to interact directly with secreted or transmembrane semaphorins, while plexins belonging to the A subfamily are suggested to make complexes with other membrane proteins, neuropilins, and propagate chemorepulsive signals of secreted semaphorins of class 3 into cells or neurons. Despite that much information has been gathered on the plexin-semaphorin interaction, the role of plexins in the nervous system is not well understood. To gain insight into the functions of plexins in the nervous system, we analyzed spatial and temporal expression patterns of three members of the plexin-A subfamily (plexin-A1, -A2, and -A3) in the developing mouse nervous system by in situ hybridization analysis in combination with immunohistochemistry. We show that the three plexins are differentially expressed in sensory receptors or neurons in a developmentally regulated manner, suggesting that a particular plexin or set of plexins is shared by neuronal elements and functions as the receptor for semaphorins to regulate neuronal development.",
author = "Yasunori Murakami and Fumikazu Suto and Masayuki Shimizu and Tomoyasu Shinoda and Toshiki Kameyama and Hajime Fujisawa",
year = "2001",
month = "3",
day = "6",
doi = "10.1002/1097-0177(20010301)220:3<246::AID-DVDY1112>3.0.CO;2-2",
language = "English",
volume = "220",
pages = "246--258",
journal = "Developmental Dynamics",
issn = "1058-8388",
publisher = "Wiley-Liss Inc.",
number = "3",

}

Differential expression of plexin-A subfamily members in the mouse nervous system. / Murakami, Yasunori; Suto, Fumikazu; Shimizu, Masayuki; Shinoda, Tomoyasu; Kameyama, Toshiki; Fujisawa, Hajime.

:: Developmental Dynamics, 巻 220, 番号 3, 06.03.2001, p. 246-258.

研究成果: Article

TY - JOUR

T1 - Differential expression of plexin-A subfamily members in the mouse nervous system

AU - Murakami, Yasunori

AU - Suto, Fumikazu

AU - Shimizu, Masayuki

AU - Shinoda, Tomoyasu

AU - Kameyama, Toshiki

AU - Fujisawa, Hajime

PY - 2001/3/6

Y1 - 2001/3/6

N2 - Plexins comprise a family of transmembrane proteins (the plexin family) which are expressed in nervous tissues. Some plexins have been shown to interact directly with secreted or transmembrane semaphorins, while plexins belonging to the A subfamily are suggested to make complexes with other membrane proteins, neuropilins, and propagate chemorepulsive signals of secreted semaphorins of class 3 into cells or neurons. Despite that much information has been gathered on the plexin-semaphorin interaction, the role of plexins in the nervous system is not well understood. To gain insight into the functions of plexins in the nervous system, we analyzed spatial and temporal expression patterns of three members of the plexin-A subfamily (plexin-A1, -A2, and -A3) in the developing mouse nervous system by in situ hybridization analysis in combination with immunohistochemistry. We show that the three plexins are differentially expressed in sensory receptors or neurons in a developmentally regulated manner, suggesting that a particular plexin or set of plexins is shared by neuronal elements and functions as the receptor for semaphorins to regulate neuronal development.

AB - Plexins comprise a family of transmembrane proteins (the plexin family) which are expressed in nervous tissues. Some plexins have been shown to interact directly with secreted or transmembrane semaphorins, while plexins belonging to the A subfamily are suggested to make complexes with other membrane proteins, neuropilins, and propagate chemorepulsive signals of secreted semaphorins of class 3 into cells or neurons. Despite that much information has been gathered on the plexin-semaphorin interaction, the role of plexins in the nervous system is not well understood. To gain insight into the functions of plexins in the nervous system, we analyzed spatial and temporal expression patterns of three members of the plexin-A subfamily (plexin-A1, -A2, and -A3) in the developing mouse nervous system by in situ hybridization analysis in combination with immunohistochemistry. We show that the three plexins are differentially expressed in sensory receptors or neurons in a developmentally regulated manner, suggesting that a particular plexin or set of plexins is shared by neuronal elements and functions as the receptor for semaphorins to regulate neuronal development.

UR - http://www.scopus.com/inward/record.url?scp=0035101766&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035101766&partnerID=8YFLogxK

U2 - 10.1002/1097-0177(20010301)220:3<246::AID-DVDY1112>3.0.CO;2-2

DO - 10.1002/1097-0177(20010301)220:3<246::AID-DVDY1112>3.0.CO;2-2

M3 - Article

C2 - 11241833

AN - SCOPUS:0035101766

VL - 220

SP - 246

EP - 258

JO - Developmental Dynamics

JF - Developmental Dynamics

SN - 1058-8388

IS - 3

ER -