Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity

Kayou Narita; Naoki Koide; Akiko Morikawa; Yutaka Kato; Tsuyoshi Sugiyama; Tomoaki Yoshida; Takashi Yokochi

doi:10.7883/yoken1952.50.233

Differential release of endotoxin from pseudomonas aeruginosa treated with β-lactam antibiotics and its effect on the lethal activity

Kayou Narita, Naoki Koide, Akiko Morikawa, Yutaka Kato, Tsuyoshi Sugiyama, Tomoaki Yoshida, Takashi Yokochi

生命科学

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

4 被引用数 (Scopus)

抄録

The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.

本文言語	英語
ページ（範囲）	233-239
ページ数	7
ジャーナル	Japanese Journal of Medical Science and Biology
巻	50
号	6
DOI	https://doi.org/10.7883/yoken1952.50.233
出版ステータス	出版済み - 12-1997

All Science Journal Classification (ASJC) codes

生化学、遺伝学、分子生物学一般

文献へのアクセス

10.7883/yoken1952.50.233

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引用スタイル

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abstract = "The relationship between the level of endotoxin released from Pseudomonas aeruginosa by exposure to β-lactam antibiotics and the lethal activity against D-galactosamine (D-GalN)-sensitized mice was examined. In vitro treatment of P. aeruginosa with imipenem (IPM) exclusively caused low-level release of free endotoxin, which was not lethal for D-GalN-sensitized mice. Treatment with other β-lactam antibiotics, such as ceftazidime (CAZ), meropenem (MEPM) and cefozopran (CZOP) caused high-level release of free endotoxin and it exhibited the lethal action against D-GalN-sensitized mice. This study demonstrated close association of free endotoxin released by antibiotic treatment with the lethal activity.",

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AU - Narita, Kayou

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AU - Sugiyama, Tsuyoshi

AU - Yoshida, Tomoaki

AU - Yokochi, Takashi

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