Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy

Masashi Mizokami, Johnson Y.N. Lau, Kaoru Suzuki, Tatsunori Nakano, Takashi Gojobori

研究成果: Article査読

26 被引用数 (Scopus)

抄録

The quasispecies nature of hepatitis C virus was investigated in a patient with chronic hepatitis C virus infection who underwent interferon-α therapy. The hepatitis C virus E2/NS1 region was amplified and cloned, and multiple clones were sequenced before and after interferon-α therapy. The hepatitis C virus quasispecies can be grouped into three groups by phylogenetic tree analysis. Quasispecies from all the groups were present before interferon-α therapy. However, only group 3 remained after interferon-α therapy. In addition, only group 3 hepatitis C virus quasispecies were present during the early biochemical relapse. These data indicate that various groups of hepatitis C virus quasispecies may have different sensitivity to interferon-α.

本文言語English
ページ(範囲)884-886
ページ数3
ジャーナルJournal of Hepatology
21
5
DOI
出版ステータスPublished - 1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 肝臓学

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