Differentiation of cancer from atrial fibrillation in patients with acute multifocal stroke

Shinji Ito, Akihiro Ueda, Kenichiro Murate, Seiko Hirota, Takao Fukui, Tomomasa Ishikawa, Sayuri Shima, Chika Hikichi, Yasuaki Mizutani, Madoka Kizawa, Kunihiko Asakura, Tatsuro Mutoh

研究成果: ジャーナルへの寄稿学術論文査読

11 被引用数 (Scopus)


Objective Acute multifocal embolic infarction (AMEI) is conventionally caused by etiologies such as cardioembolism due to atrial fibrillation (Af), but can also be caused by serious underlying diseases such as cancer. We characterized cancer-related AMEI and identified useful indicators for cancer-associated strokes. Methods A retrospective analysis was performed on 35 patients with Af-related AMEI and 35 patients with cancer-related AMEI selected from 1235 consecutive patients with acute infarcts. All patients received diffusion-weighted magnetic resonance (MR) imaging. Cerebral MR angiography, carotid and cardiac ultrasonography, electrocardiogram-monitoring and whole body computed tomography were also performed on these patients. D-dimer levels were evaluated on admission, and were measured during the sub-acute phase in 19 of the patients with Af and 27 of the patients with cancer. Results Acute phase D-dimer levels were significantly higher in patients with cancer than in patients with Af alone. The cut-off D-dimer value to identify cancer-associated infarcts was 2.0 μg/mL. D-dimer levels during the sub-acute phase remained elevated in the cancer patients. Conclusions We may differentiate cancer-associated AMEI from Af using a D-dimer level ≥ 2.0 μg/mL, which does not decrease during the sub-acute phase.

ジャーナルJournal of the Neurological Sciences
出版ステータス出版済み - 15-09-2016

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学


「Differentiation of cancer from atrial fibrillation in patients with acute multifocal stroke」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。