Diffusion-tensor neuronal fiber tractography and manganese- Enhanced MR imaging of primate visual pathway in the common marmoset: Preliminary results

Masayuki Yamada, Suketaka Momoshima, Yoshitaka Masutani, Kanehiro Fujiyoshi, Osamu Abe, Masaya Nakamura, Shigeki Aoki, Norikazu Tamaoki, Hideyuki Okano

研究成果: Article

35 引用 (Scopus)

抄録

Purpose: To investigate whether diffusion-tensor tractography (DTT) of neuronal fibers is useful for delineating the configuration of the neuronal fiber trajectories in the primate visual pathway, including the well-developed optic chiasm, in comparison with tract tracing at manganese-enhanced magnetic resonance (MR) imaging. Materials and Methods: The handling methods used for all the animals in this study were approved by the institutional committee for animal experiments. Diffusion-tensor MR imaging was performed in four healthy common marmosets, and in two of these animals, manganese-enhanced MR imaging tract tracing was performed by using a 7.0-T MR imaging unit. The visual pathways were quantitatively investigated in terms of the manganese distribution observed on the manganese- enhanced MR images. The images obtained with DTT and manganese-enhanced MR imaging tract tracing were qualitatively compared, and the features of the visual pathway were verified through fusion of the reconstructed images obtained by using these two modalities. Results: DTT provided information regarding the neuroanatomic features of the marmoset visual pathway and revealed the bilateral branching patterns of the typical primate retino-geniculate pathways, although several incorrectly tracked fibers were noted. The distribution of manganese on the manganese-enhanced MR images revealed bilateral innervation of the retinal projections and depicted the layered internal structure of the lateral geniculate nuclei bilaterally, depending on the ocularity of each layer. These morphologic findings were consistent with those of previous histopathologic studies. Conclusion: The findings of this preliminary study raise the possibility that DTT is useful for visualizing the neuronal fiber trajectories in primate visual pathways.

元の言語English
ページ(範囲)855-864
ページ数10
ジャーナルRadiology
249
発行部数3
DOI
出版物ステータスPublished - 01-12-2008

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Callithrix
Visual Pathways
Manganese
Primates
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Magnetic Resonance Spectroscopy
Geniculate Bodies
Optic Chiasm
Diffusion Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

これを引用

Yamada, Masayuki ; Momoshima, Suketaka ; Masutani, Yoshitaka ; Fujiyoshi, Kanehiro ; Abe, Osamu ; Nakamura, Masaya ; Aoki, Shigeki ; Tamaoki, Norikazu ; Okano, Hideyuki. / Diffusion-tensor neuronal fiber tractography and manganese- Enhanced MR imaging of primate visual pathway in the common marmoset : Preliminary results. :: Radiology. 2008 ; 巻 249, 番号 3. pp. 855-864.
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title = "Diffusion-tensor neuronal fiber tractography and manganese- Enhanced MR imaging of primate visual pathway in the common marmoset: Preliminary results",
abstract = "Purpose: To investigate whether diffusion-tensor tractography (DTT) of neuronal fibers is useful for delineating the configuration of the neuronal fiber trajectories in the primate visual pathway, including the well-developed optic chiasm, in comparison with tract tracing at manganese-enhanced magnetic resonance (MR) imaging. Materials and Methods: The handling methods used for all the animals in this study were approved by the institutional committee for animal experiments. Diffusion-tensor MR imaging was performed in four healthy common marmosets, and in two of these animals, manganese-enhanced MR imaging tract tracing was performed by using a 7.0-T MR imaging unit. The visual pathways were quantitatively investigated in terms of the manganese distribution observed on the manganese- enhanced MR images. The images obtained with DTT and manganese-enhanced MR imaging tract tracing were qualitatively compared, and the features of the visual pathway were verified through fusion of the reconstructed images obtained by using these two modalities. Results: DTT provided information regarding the neuroanatomic features of the marmoset visual pathway and revealed the bilateral branching patterns of the typical primate retino-geniculate pathways, although several incorrectly tracked fibers were noted. The distribution of manganese on the manganese-enhanced MR images revealed bilateral innervation of the retinal projections and depicted the layered internal structure of the lateral geniculate nuclei bilaterally, depending on the ocularity of each layer. These morphologic findings were consistent with those of previous histopathologic studies. Conclusion: The findings of this preliminary study raise the possibility that DTT is useful for visualizing the neuronal fiber trajectories in primate visual pathways.",
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Yamada, M, Momoshima, S, Masutani, Y, Fujiyoshi, K, Abe, O, Nakamura, M, Aoki, S, Tamaoki, N & Okano, H 2008, 'Diffusion-tensor neuronal fiber tractography and manganese- Enhanced MR imaging of primate visual pathway in the common marmoset: Preliminary results', Radiology, 巻. 249, 番号 3, pp. 855-864. https://doi.org/10.1148/radiol.2493072141

Diffusion-tensor neuronal fiber tractography and manganese- Enhanced MR imaging of primate visual pathway in the common marmoset : Preliminary results. / Yamada, Masayuki; Momoshima, Suketaka; Masutani, Yoshitaka; Fujiyoshi, Kanehiro; Abe, Osamu; Nakamura, Masaya; Aoki, Shigeki; Tamaoki, Norikazu; Okano, Hideyuki.

:: Radiology, 巻 249, 番号 3, 01.12.2008, p. 855-864.

研究成果: Article

TY - JOUR

T1 - Diffusion-tensor neuronal fiber tractography and manganese- Enhanced MR imaging of primate visual pathway in the common marmoset

T2 - Preliminary results

AU - Yamada, Masayuki

AU - Momoshima, Suketaka

AU - Masutani, Yoshitaka

AU - Fujiyoshi, Kanehiro

AU - Abe, Osamu

AU - Nakamura, Masaya

AU - Aoki, Shigeki

AU - Tamaoki, Norikazu

AU - Okano, Hideyuki

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Purpose: To investigate whether diffusion-tensor tractography (DTT) of neuronal fibers is useful for delineating the configuration of the neuronal fiber trajectories in the primate visual pathway, including the well-developed optic chiasm, in comparison with tract tracing at manganese-enhanced magnetic resonance (MR) imaging. Materials and Methods: The handling methods used for all the animals in this study were approved by the institutional committee for animal experiments. Diffusion-tensor MR imaging was performed in four healthy common marmosets, and in two of these animals, manganese-enhanced MR imaging tract tracing was performed by using a 7.0-T MR imaging unit. The visual pathways were quantitatively investigated in terms of the manganese distribution observed on the manganese- enhanced MR images. The images obtained with DTT and manganese-enhanced MR imaging tract tracing were qualitatively compared, and the features of the visual pathway were verified through fusion of the reconstructed images obtained by using these two modalities. Results: DTT provided information regarding the neuroanatomic features of the marmoset visual pathway and revealed the bilateral branching patterns of the typical primate retino-geniculate pathways, although several incorrectly tracked fibers were noted. The distribution of manganese on the manganese-enhanced MR images revealed bilateral innervation of the retinal projections and depicted the layered internal structure of the lateral geniculate nuclei bilaterally, depending on the ocularity of each layer. These morphologic findings were consistent with those of previous histopathologic studies. Conclusion: The findings of this preliminary study raise the possibility that DTT is useful for visualizing the neuronal fiber trajectories in primate visual pathways.

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