Diisopropylfluorophosphate and GABA synaptic function

Effect on levels, enzymes, release and uptake in the rat striatum

S. P. Sivam, Toshitaka Nabeshima, D. K. Lim, B. Hoskins, I. K. Ho

研究成果: Article

17 引用 (Scopus)

抄録

The present study revealed that diisopropylfluorophosphate increased the GABA and glutamate levels, decreased the uptake of GABA, decreased the spontaneous release of GABA and did not exhibit its effects on the metabolic enzymes of GABA, glutamic acid decarboxylase and GABA-transaminase. These results, together with our previous findings that the postsynaptic GABA receptor population is increased by DFP treatment, indicate that GABA transmission is affected by DFP. An overall enhancement of GABA function appears to be involved in DFP poisoning; it is suggested that this may be a compensatory mechanism to counteract the cholinergic hyperactivity.

元の言語English
ページ(範囲)51-60
ページ数10
ジャーナルResearch Communications in Chemical Pathology and Pharmacology
42
発行部数1
出版物ステータスPublished - 01-12-1983

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Isoflurophate
gamma-Aminobutyric Acid
Rats
Enzymes
4-Aminobutyrate Transaminase
GABA Receptors
Glutamate Decarboxylase
Poisoning
Cholinergic Agents
Glutamic Acid
Population

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

これを引用

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