Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases

Yoshiaki Shinden; Sayuri Akiyoshi; Hiroki Ueo; Syo Nambara; Tomoko Saito; Hisateru Komatsu; Masami Ueda; Hidenari Hirata; Shotaro Sakimura; Ryutaro Uchi; Yuki Takano; Tomohiro Iguchi; Hidetoshi Eguchi; Keishi Sugimachi; Yuko Kijima; Hiroaki Ueo; Shoji Natsugoe; Koshi Mimori

Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases

Yoshiaki Shinden
, Sayuri Akiyoshi
, Hiroki Ueo
, Syo Nambara
, Tomoko Saito
, Hisateru Komatsu
, Masami Ueda
, Hidenari Hirata
, Shotaro Sakimura
, Ryutaro Uchi
, Yuki Takano
, Tomohiro Iguchi
, Hidetoshi Eguchi
, Keishi Sugimachi
, Yuko Kijima
, Hiroaki Ueo
, Shoji Natsugoe
, Koshi Mimori

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

抄録

Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.

Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.

Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].

Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

本文言語	英語
ページ（範囲）	123-128
ページ数	6
ジャーナル	Anticancer research
巻	35
号	1
出版ステータス	出版済み - 01-01-2015
外部発表	はい

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腫瘍学
癌研究

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@article{f4b5ec1af62a4eb4af1ce83607c287d3,

title = "Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases",

abstract = "Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.",

author = "Yoshiaki Shinden and Sayuri Akiyoshi and Hiroki Ueo and Syo Nambara and Tomoko Saito and Hisateru Komatsu and Masami Ueda and Hidenari Hirata and Shotaro Sakimura and Ryutaro Uchi and Yuki Takano and Tomohiro Iguchi and Hidetoshi Eguchi and Keishi Sugimachi and Yuko Kijima and Hiroaki Ueo and Shoji Natsugoe and Koshi Mimori",

year = "2015",

month = jan,

day = "1",

language = "English",

volume = "35",

pages = "123--128",

journal = "Anticancer research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

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}

TY - JOUR

T1 - Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases

AU - Shinden, Yoshiaki

AU - Akiyoshi, Sayuri

AU - Ueo, Hiroki

AU - Nambara, Syo

AU - Saito, Tomoko

AU - Komatsu, Hisateru

AU - Ueda, Masami

AU - Hirata, Hidenari

AU - Sakimura, Shotaro

AU - Uchi, Ryutaro

AU - Takano, Yuki

AU - Iguchi, Tomohiro

AU - Eguchi, Hidetoshi

AU - Sugimachi, Keishi

AU - Kijima, Yuko

AU - Ueo, Hiroaki

AU - Natsugoe, Shoji

AU - Mimori, Koshi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

AB - Background/Aim: MiR-15a targets Cyclin E1 (CCNE1), which regulates the cell cycle and promotes cell proliferation and progression. Herein, we investigated the clinicopathological significance of miR-15a as a prognostic marker in breast cancer (BC) cases.Materials and Methods: We collected primary tumor samples of 230 BC cases, including 68 triple-negative cases. The expression levels of miR-15a in primary tumors were measured by qRT-PCR assay.Results: Low expression of miR-15a in primary tumors was significantly correlated with shorter disease-free survival (p=0.0012) and overall survival (p=0.005) compared to the high miR-15a expression in triple-negative BC cases. Multivariate analysis indicated that low miR-15a expression was an independent prognostic factor for overall survival [RR=2.56(1.03-7.18), p=0.04].Conclusion: MiR-15a expression levels could be a promising biological and prognostic marker for overall survival especially in triple-negative BC cases.

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UR - https://www.scopus.com/pages/publications/84920460491#tab=citedBy

M3 - Article

C2 - 25550542

AN - SCOPUS:84920460491

SN - 0250-7005

VL - 35

SP - 123

EP - 128

JO - Anticancer research

JF - Anticancer research

IS - 1

ER -

Diminished expression of MiR-15a is an independent prognostic marker for breast cancer cases

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