Disrupted Brain Activation and Deactivation Pattern during Semantic Verbal Fluency Task in Patients with Major Depression

Masahiro Takamura, Yasumasa Okamoto, Go Okada, Shigeru Toki, Tetsuya Yamamoto, Osamu Yamamoto, Hiroaki Jitsuiki, Norio Yokota, Tatsuji Tamura, Akiko Kurata, Yoko Kaichi, Yuji Akiyama, Kazuo Awai, Shigeto Yamawaki

研究成果: ジャーナルへの寄稿学術論文査読

28 被引用数 (Scopus)

抄録

Background: Patients with major depressive disorder (MDD) exhibit cognitive impairment, and evidence suggests that the semantic version of the verbal fluency task is a reliable cognitive marker of the disorder. Here, using functional magnetic resonance imaging (fMRI), we investigated the dysfunction of neural processing in acute depression and examined the effects of a 6-week pharmacological intervention. Methods: Sixteen patients with MDD participated in 2 fMRI sessions, and 16 healthy control (HC) subjects participated in 1 fMRI session. During each fMRI session, the participants performed a semantic verbal fluency task. Brain activity during the task was compared between groups (MDD 1st fMRI vs. HC) and times (MDD 1st fMRI vs. 2nd fMRI). Results: Significant brain hypoactivation was observed in MDD patients at the prefrontal, lateral parietal, and limbic regions compared to HC, and MDD patients exhibited hyperactivation at the left precuneus compared to HC. Hypoactivity of the left dorsolateral prefrontal cortex (DLPFC) and hyperactivity of the precuneus were normalized with treatment. Conclusions: Hypoactivation of the left DLPFC and hyperactivation of the precuneus should be considered as dysregulation of anticorrelated brain networks during a cognitive demanding task. This failure of network regulation may be an important factor in the pathophysiology of MDD.

本文言語英語
ページ(範囲)69-77
ページ数9
ジャーナルNeuropsychobiology
74
2
DOI
出版ステータス出版済み - 01-04-2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経心理学および生理心理学
  • 精神医学および精神衛生
  • 生物学的精神医学

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