Disrupted-In-Schizophrenia-1 (DISC1) regulates transport and translation of neuronal mRNA in hippocampal neurons

研究成果: ジャーナルへの寄稿簡易調査査読

2 被引用数 (Scopus)


Disrupted-In-Schizophrenia 1 (DISC1) is one of the most promising susceptibility genes for major psychiatric disorders including schizophrenia and major depression. DISC1 is implicated in neuronal developments like neurogenesis, neuronal migration, axon/dendrite formation and synapse formation. We previously found that DISC1 links Kinesin-1 to Nudel/Lis1 and Grb2 and regulates their anterograde transport into axons of hippocampal neurons as a cargo adaptor (Taya et al, 2007). However, its modes of action remain largely unknown. Here, we comprehensively screened the DISC1-interacting proteins by combining affinity column and shot gun LC/MS/MS, and identified many RNA-binding proteins including Hzf, which acts as a component of RNA granules and participates in the dendritic transport of IP3 receptor 1 (IP3R1) mRNA DISC1 directly interacted with Hzf and co-localized with Hzf and RNA granules in hippocampal dendrites. DISC1 directly associated with IP3R1 mRNA and was co-transported into dendrites. The impairments of DISC1 functions prohibited dendritic transport and translation of IP3R1 mRNA Together, these results suggest that DISC1 together with Hzf interacts with a specific mRNAs such as IP3R1 mRNA and regulates their dendritic transport via Kinesin-1 and translation as a component of RNA granules.

ジャーナルJapanese Journal of Neuropsychopharmacology
出版ステータス出版済み - 06-2010

All Science Journal Classification (ASJC) codes

  • 臨床心理学
  • 薬理学
  • 精神医学および精神衛生
  • 薬理学(医学)


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