TY - JOUR
T1 - Distribution of PAPP-A and total hCG between 11 and 13 weeks of gestation in Japanese pregnant women
AU - on behalf of Study group for first trimester Combined Test (FCTG)
AU - Hasegawa, Junichi
AU - Wada, Seiji
AU - Kasamatsu, Atsushi
AU - Nakamura, Masamitsu
AU - Hamanoue, Haruka
AU - Iwata, Eriko
AU - Murotsuki, Jun
AU - Nagai, Ryuhei
AU - Tateishi, Yoko
AU - Sunami, Rei
AU - Tajima, Atsushi
AU - Murata, Susumu
AU - Matsubara, Keiichi
AU - Nakata, Masahiko
AU - Kondo, Akane
AU - Nishiyama, Miyuki
AU - Sasaki, Aiko
AU - Sekizawa, Akihiko
AU - Sago, Haruhiko
AU - Kamei, Yoshimasa
N1 - Publisher Copyright:
© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/6/17
Y1 - 2020/6/17
N2 - Objectives: To establish the reference values for PAPP-A and total hCG between 11 and 13 weeks of gestation for the use of risk assessment of fetal aneuploidy in Japanese pregnant women. Methods: A multicenter prospective study was conducted. The subjects included only Japanese pregnant women with viable singleton who requested the first trimester combined (nuchal translucency and maternal serum marker) screening for fetal aneuploidy. Reference values of PAPP-A and total hCG in Japanese population were made and compared with them in Caucasian. Results: Overall 1,751 Japanese pregnant women were analyzed. Median vales of maternal serum concentration in Japanese pregnant women from 11 + 0–13 + 6 weeks’ gestation were ranged from 3.01 to 9.51 mIU/mL for PAPP-A and from 70.2 to 58.3 IU/mL for total-hCG, respectively. Regression curve of median maternal serum PAPP-A and total-hCG concentration against gestational days are significantly higher in Japanese comparing with Caucasian. At most distant values, Japanese serum concentration indicated 1.45 MoM for total-hCG and 1.70 MoM for PAPP-A based on Caucasian regression curves. Conclusion: A modification of the equations by specific reference values is necessary for Japanese pregnant women at the risk assessment of chromosomal abnormalities using the first trimester maternal serum marker.
AB - Objectives: To establish the reference values for PAPP-A and total hCG between 11 and 13 weeks of gestation for the use of risk assessment of fetal aneuploidy in Japanese pregnant women. Methods: A multicenter prospective study was conducted. The subjects included only Japanese pregnant women with viable singleton who requested the first trimester combined (nuchal translucency and maternal serum marker) screening for fetal aneuploidy. Reference values of PAPP-A and total hCG in Japanese population were made and compared with them in Caucasian. Results: Overall 1,751 Japanese pregnant women were analyzed. Median vales of maternal serum concentration in Japanese pregnant women from 11 + 0–13 + 6 weeks’ gestation were ranged from 3.01 to 9.51 mIU/mL for PAPP-A and from 70.2 to 58.3 IU/mL for total-hCG, respectively. Regression curve of median maternal serum PAPP-A and total-hCG concentration against gestational days are significantly higher in Japanese comparing with Caucasian. At most distant values, Japanese serum concentration indicated 1.45 MoM for total-hCG and 1.70 MoM for PAPP-A based on Caucasian regression curves. Conclusion: A modification of the equations by specific reference values is necessary for Japanese pregnant women at the risk assessment of chromosomal abnormalities using the first trimester maternal serum marker.
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U2 - 10.1080/14767058.2018.1536737
DO - 10.1080/14767058.2018.1536737
M3 - Article
C2 - 30318933
AN - SCOPUS:85057779886
SN - 1476-7058
VL - 33
SP - 2017
EP - 2022
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
IS - 12
ER -