Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse

Feng Xu, Yusuke Sudo, Sho Sanechika, Junpei Yamashita, Sho Shimaguchi, Shun Ichiro Honda, Chiho Sumi-Ichinose, Masayo Mori-Kojima, Rieko Nakata, Tadaomi Furuta, Minoru Sakurai, Masahiro Sugimoto, Tomoyoshi Soga, Kazunao Kondo, Hiroshi Ichinose

研究成果: Article査読

13 被引用数 (Scopus)


Quinonoid dihydropteridine reductase (QDPR) catalyzes the regeneration of tetrahydrobiopterin (BH4), a cofactor for monoamine synthesis, phenylalanine hydroxylation and nitric oxide production. Here, we produced and analyzed a transgenic Qdpr-/- mouse model. Unexpectedly, the BH4 contents in the Qdpr-/- mice were not decreased and even increased in some tissues, whereas those of the oxidized form dihydrobiopterin (BH2) were significantly increased. We demonstrated that unlike the wild-type mice, dihydrofolate reductase regenerated BH4 from BH2 in the mutants. Furthermore, we revealed wide alterations in folate-associated metabolism in the Qdpr-/- mice, which suggests an interconnection between folate and biopterin metabolism in the transgenic mouse model.

ジャーナルFEBS Letters
出版ステータスPublished - 03-11-2014

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

フィンガープリント 「Disturbed biopterin and folate metabolism in the Qdpr-deficient mouse」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。