Diverse long-range axonal projections of excitatory layer 2/3 neurons in mouse barrel cortex

Takayuki Yamashita, Angeliki Vavladeli, Aurélie Pala, Katia Galan, Sylvain Crochet, Sara S.A. Petersen, Carl C.H. Petersen

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Excitatory projection neurons of the neocortex are thought to play important roles in perceptual and cognitive functions of the brain by directly connecting diverse cortical and subcortical areas. However, many aspects of the anatomical organization of these inter-areal connections are unknown. Here, we studied long-range axonal projections of excitatory layer 2/3 neurons with cell bodies located in mouse primary somatosensory barrel cortex (wS1). As a population, these neurons densely projected to secondary whisker somatosensory cortex (wS2) and primary/secondary whisker motor cortex (wM1/2), with additional axon in the dysgranular zone surrounding the barrel field, perirhinal temporal association cortex and striatum. In three-dimensional reconstructions of 6 individual wS2-projecting neurons and 9 individual wM1/2-projecting neurons, we found that both classes of neurons had extensive local axon in layers 2/3 and 5 of wS1. Neurons projecting to wS2 did not send axon to wM1/2, whereas a small subset of wM1/2-projecting neurons had relatively weak projections to wS2. A small fraction of projection neurons solely targeted wS2 or wM1/2. However, axon collaterals from wS2-projecting and wM1/2-projecting neurons were typically also found in subsets of various additional areas, including the dysgranular zone, perirhinal temporal association cortex and striatum. Our data suggest extensive diversity in the axonal targets selected by individual nearby cortical long-range projection neurons with somata located in layer 2/3 of wS1.

本文言語English
論文番号33
ジャーナルFrontiers in Neuroanatomy
12
DOI
出版ステータスPublished - 01-05-2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 解剖学
  • 神経科学(その他)
  • 細胞および分子神経科学

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