Dopamine receptor DOP1R2 stabilizes appetitive olfactory memory through the Raf/MAPK pathway in Drosophila

Huan Sun, Tomoki Nishioka, Shun Hiramatsu, Shu Kondo, Mutsuki Amano, Kozo Kaibuchi, Toshiharu Ichinose, Hiromu Tanimoto

研究成果: Article査読

3 被引用数 (Scopus)

抄録

In Drosophila, dopamine signaling to the mushroom body intrinsic neurons, Kenyon cells (KCs), is critical to stabilize olfactory memory. Little is known about the downstream intracellular molecular signaling underlying memory stabilization. Here we address this question in the context of sugar-rewarded olfactory long-term memory (LTM). We show that associative training increases the phosphorylation of MAPK in KCs, via Dop1R2 signaling. Consistently, the attenuation of Dop1R2, Raf, or MAPK expression in KCs selectively impairs LTM, but not short-term memory. Moreover, we show that the LTM deficit caused by the knockdown of Dop1R2 can be rescued by expressing active Raf in KCs. Thus, the Dop1R2/Raf/MAPK pathway is a pivotal downstream effector of dopamine signaling for stabilizing appetitive olfactory memory.

本文言語English
ページ(範囲)2935-2942
ページ数8
ジャーナルJournal of Neuroscience
40
14
DOI
出版ステータスPublished - 01-04-2020
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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