Dynamic contrast-enhanced perfusion area detector CT for non-small cell lung cancer patients: Influence of mathematical models on early prediction capabilities for treatment response and recurrence after chemoradiotherapy

Yoshiharu Ohno, Hisanobu Koyama, Yasuko Fujisawa, Takeshi Yoshikawa, Shinichiro Seki, Naoki Sugihara, Kazuro Sugimura

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Purpose To determine the capability and influence of the mathematical method on dynamic contrast-enhanced (CE-) perfusion area detector CT (ADCT) for early prediction of treatment response as well as progression free and overall survival (PFS and OS) of non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy. Materials and methods Sixty-six consecutive stage III NSCLC patients underwent dynamic CE-perfusion ADCT examinations, chemoradiotherapy and follow-up examinations. Response Evaluation Criteria in Solid Tumors (RECIST) criteria were used to divide all patients into responders and non-responders. Differences in each of the indices for all targeted lesions between measurements obtained 2 weeks prior to the first and the third course of chemotherapy were determined for all patients. ROC analyses were employed to determine the capability of perfusion indices as markers for distinguishing RECIST responders from non-responders. To evaluate their capability for early prediction of therapeutic effect, OS of perfusion index-based responders and non-responders were compared by using the Kaplan-Meier method followed by log-rank test. Results Area under the curve (Az) for total perfusion by means of the dual-input maximum slope method was significantly larger than that of pulmonary arterial perfusion using the same method (p = 0.007) and of perfusion with the single-input maximum slope method (p = 0.007). Mean OS demonstrated significantly difference between responder- and non-responder groups for total perfusion (p = 0.02). Conclusion Mathematical models have significant influence on assessment for early prediction of treatment response, disease progression and overall survival using dynamic CE-perfusion ADCT for NSCLC patients treated with chemoradiotherapy.

本文言語English
ページ(範囲)176-186
ページ数11
ジャーナルEuropean journal of radiology
85
1
DOI
出版ステータスPublished - 01-01-2016
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

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