Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy

Yasushi Takeichi, Kohzo Nagata, Hideo Izawa, Mitsunori Iwase, Toshikazu Sobue, Motoaki Sugawara, Mitsuhiro Yokota

研究成果: Article

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We investigated the effect of mild exercise on global and regional diastolic function in patients with hypertensive left ventricular hypertrophy (LVH), using simultaneous measurement of micromanometric left ventricular pressure and echocardiographic indexes. Although left ventricular end-diastolic pressure (LVEDP) at rest in the hypertensive LVH group was similar to that in the control normotensive group, who had no abnormality on echocardiography or cardiac catheterization, LVEDP showed a marked increase during exercise only in the hypertensive LVH group. The pressure-dimension relation was shifted upward during exercise in all patients with hypertensive LVH. We utilized a new index of regional diastolic myocardial stiffness, KDM, which is derived from the diastolic relation between the mean wall stress and the natural logarithm of the reciprocal of wall thickness. Although KDM at rest was similar in the two groups, KDM increased significantly during exercise, both in the septum and posterior wall in patients with hypertensive LVH. The present results imply that even low-grade exercise may have deleterious effects on regional myocardial performance in patients with hypertensive LVH.

元の言語English
ページ(範囲)138-141
ページ数4
ジャーナルHeart and Vessels
12
発行部数SUPPL. 12
出版物ステータスPublished - 1997

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Takeichi, Y., Nagata, K., Izawa, H., Iwase, M., Sobue, T., Sugawara, M., & Yokota, M. (1997). Dynamic exercise-induced changes in diastolic properties of the regional myocardium in hypertensive left ventricular hypertrophy. Heart and Vessels, 12(SUPPL. 12), 138-141.