Dynamic perfusion MRI: Capability for evaluation of disease severity and progression of pulmonary arterial hypertension in patients with connective tissue disease

Yoshiharu Ohno, Hisanobu Koyama, Munenobu Nogami, Daisuke Takenaka, Sumiaki Matsumoto, Yumiko Onishi, Keiko Matsumoto, Kenya Murase, Kazuro Sugimura

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Purpose: To prospectively evaluate the capability of dynamic perfusion MRI for assessment of disease severity and progression to pulmonary arterial hypertension (PAH) in connective tissue disease (CTD) patients. Materials and Methods: In all, 18 gender- and age-matched CTD patients without and with PAH and nine healthy volunteers underwent dynamic perfusion MRI, Doppler echocardiography, and pulmonary function test. Disease severity of CTD was assessed in terms of diffusing capacity for carbon monoxide (%DLCO) and estimated systolic pulmonary arterial pressure (sPAP), and progression of PAH in terms of pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). From calculated pulmonary perfusion parameter maps, means of pulmonary blood flow (mPBF), pulmonary blood volume (mPBV), and mean transit time (mMTT) were determined as averages of all region of interest (ROI) measurements. To determine disease severity in CTD, all parameters were statistically correlated with sPAP and %DLCO. To determine progression to PAH, all parameters were statistically correlated with mPAP and PVR. Results: All pulmonary perfusion parameters correlated significantly with sPAP and %DLCO (P < 0.05). mPBF and mPBV correlated significantly with mPAP and moderately with PVR (P < 0.05). Conclusion: Dynamic perfusion MRI can be used for assessment of disease severity and progression of PAH in CTD patients.

本文言語English
ページ(範囲)887-899
ページ数13
ジャーナルJournal of Magnetic Resonance Imaging
28
4
DOI
出版ステータスPublished - 10-2008
外部発表はい

All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング

フィンガープリント

「Dynamic perfusion MRI: Capability for evaluation of disease severity and progression of pulmonary arterial hypertension in patients with connective tissue disease」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル