Dysfunction of cholinergic and dopaminergic neuronal systems in β-amyloid protein-infused rats

Akio Itoh, Atsumi Nitta, Masayuki Nadai, Kyoko Nishimura, Mitsuhiko Hirose, Takaaki Hasegawa, Toshitaka Nabeshima

研究成果: ジャーナルへの寄稿学術論文査読

137 被引用数 (Scopus)

抄録

Accumulations of β-amyloid protein are characteristic and diagnostic features of the brain of Alzheimer's disease patients; however, the physiological role of this protein in CNS is unknown. We have previously reported that continuous infusion of β-amyloid protein into rat cerebral ventricle impairs learning ability and decreases choline acetyltransferase activity, a marker enzyme of cholinergic neuron. In this study, the effects of β-amyloid protein infusion on the release of neurotransmitters in cholinergic and dopaminergic neuronal systems were investigated by using an in vivo brain microdialysis method. Nicotine-stimulated release of acetylcholine and dopamine in these animals was significantly lower than that in vehicle-infused rats. Further, dopamine release induced by high-K stimulation was decreased in β-amyloid protein-infused rats compared with vehicle-infused rats. These results suggest that the release of the two transmitters, acetylcholine and dopamine, was decreased by β-amyloid protein and that learning deficits observed in the β-amyloid protein-infused rats are partly due to the impairment of neurotransmitter release. Furthermore, continuous infusion of β-amyloid protein may be a useful method to produce the animal model of Alzheimer's disease.

本文言語英語
ページ(範囲)1113-1117
ページ数5
ジャーナルJournal of neurochemistry
66
3
DOI
出版ステータス出版済み - 03-1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 細胞および分子神経科学

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