Early risk factors for mortality in children with seizure and/or impaired consciousness accompanied by fever without known etiology

Kazumi Tomioka, Hiroaki Nagase, Tsukasa Tanaka, Masahiro Nishiyama, Hiroshi Yamaguchi, Yusuke Ishida, Daisaku Toyoshima, Azusa Maruyama, Kyoko Fujita, Mariko Taniguchi-Ikeda, Kandai Nozu, Ichiro Morioka, Noriyuki Nishimura, Hiroshi Kurosawa, Yoshiyuki Uetani, Kazumoto Iijima

研究成果: Article査読

4 被引用数 (Scopus)

抄録

Background: Children who present with seizure and/or impaired consciousness accompanied by fever without known etiology (SICF) may be diagnosed with either acute encephalopathy (AE) or febrile seizure (FS). Although approximately 5% of AE cases are fatal, it is difficult to identify fatal cases among children with SICF, which are often critical by the time of diagnosis. Thus, early prediction of outcomes for children with SICF, prior to diagnosis, may help to reduce mortality associated with AE. The aim of the present study was to identify clinical and laboratory risk factors for mortality acquired within 6 h of onset among children with SICF. Methods: We retrospectively reviewed the medical records of children who had been admitted to Kobe Children's Hospital (Kobe, Japan) with SICF between October 2002 and September 2015. We compared clinical and laboratory characteristics acquired within 6 h of onset and outcomes between survivors and non-survivors using univariate and multivariate analyses. Results: The survivor and non-survivor groups included 659 and nine patients, respectively. All patients in the non-survivor group received a final diagnosis of AE. Univariate analysis revealed significant differences between the groups with regard to seizure duration and the following laboratory parameters: aspartate transaminase (AST), alanine aminotransferase, lactate dehydrogenase, sodium, and lactate. The multivariate analysis identified AST as a significant independent factor associated with mortality. Conclusions: Elevation of AST within 6 h of onset is independently correlated with mortality in children with SICF. Our result may elucidate earlier intervention for patients with high risk of mortality.

本文言語English
ページ(範囲)552-557
ページ数6
ジャーナルBrain and Development
40
7
DOI
出版ステータスPublished - 08-2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 発達神経科学
  • 臨床神経学

フィンガープリント

「Early risk factors for mortality in children with seizure and/or impaired consciousness accompanied by fever without known etiology」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル