[EBV-associated B-cell lymphoproliferative disorder of the elderly successfully treated with autologous peripheral blood stem cell transplantation and locoregional radiotherapy].

Noriko Sugino, Chishiho Nakamura, Sumie Fujii, Yusuke Matsui, Hitomi Kaneko, Mitsumasa Watanabe, Yasuo Miura, Tomoko Wakasa, Mitsuru Tsudo

研究成果: Article査読

抄録

Age-related EBV-associated B-cell lymphoproliferative disorder is a highly aggressive lymphoma, and a standard therapy for this disease has not yet been established. A 58-year-old male was admitted to our hospital because of fever and lymphadenopathy across the whole body. Neck lymph node biopsy showed hemorrhagic and geographic necrosis with Hodgkin-like large cells against a background of small lymphocytes. The large cells were positive for CD30 and EBER. The patient was diagnosed as having age-related EBV-associated B-cell lymphoproliferative disorder. Although there was no response to CHOP therapy, he obtained partial response after 3 courses of DeVIC therapy. Because his lymphoma was highly aggressive and chemotherapy-resistant, he underwent autologous stem cell transplantation with a conditioning regimen including ranimustine, etoposide, cytarabine, and melphalan. After stem cell transplantation and subsequent radiotherapy to the residual lesion, the patient achieved complete remission. This is the first report of successful autologous stem cell transplantation for a patient with age-related EBV-associated B-cell lymphoproliferative disorder.

本文言語English
ページ(範囲)129-135
ページ数7
ジャーナル[Rinshō ketsueki] The Japanese journal of clinical hematology
52
3
出版ステータスPublished - 01-03-2011

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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