TY - JOUR
T1 - Ectopic Adrenocorticotropic Hormone Syndrome due to Pancreatic Neuroendocrine Carcinoma
AU - Kawanishi, Aya
AU - Deguchi, Ryuzo
AU - Ito, Ayano
AU - Ueda, Takashi
AU - Tsuruya, Kota
AU - Arase, Yoshitaka
AU - Shirataki, Yoshihiro
AU - Kodama, Toshiki
AU - Morimachi, Masashi
AU - Kagawa, Tatehiro
N1 - Publisher Copyright:
© 2025 The Japanese Society of Internal Medicine.
PY - 2025/1/15
Y1 - 2025/1/15
N2 - A 55-year-old woman presented to her primary care physician with facial and lower leg edema. After being referred to our hospital because of hypothyroidism and hypokalemia on blood tests, she also had elevated adrenocorticotropic hormone (ACTH) and cortisol levels, but a dexamethasone suppression test showed no cortisol suppression. Ectopic ACTH syndrome due to pancreatic neuroendocrine carcinoma (PNEC) was suspected. endoscopic ultrasound-guided fine-needle aspiration was performed, and a histopathological examination of the obtained specimen revealed multiple liver metastases of the PNEC. Imaging after etoposide and cisplatin therapy showed cystic changes in the primary lesions and shrinkage of the liver metastases, and the ACTH levels were within the normal range.
AB - A 55-year-old woman presented to her primary care physician with facial and lower leg edema. After being referred to our hospital because of hypothyroidism and hypokalemia on blood tests, she also had elevated adrenocorticotropic hormone (ACTH) and cortisol levels, but a dexamethasone suppression test showed no cortisol suppression. Ectopic ACTH syndrome due to pancreatic neuroendocrine carcinoma (PNEC) was suspected. endoscopic ultrasound-guided fine-needle aspiration was performed, and a histopathological examination of the obtained specimen revealed multiple liver metastases of the PNEC. Imaging after etoposide and cisplatin therapy showed cystic changes in the primary lesions and shrinkage of the liver metastases, and the ACTH levels were within the normal range.
KW - ectopic adrenocorticotropic hormone syndrome
KW - endoscopic ultrasound-guided fine-needle aspiration
KW - pancreatic neuroendocrine carcinoma
KW - pancreatic neuroendocrine neoplasms
UR - https://www.scopus.com/pages/publications/85214971116
UR - https://www.scopus.com/pages/publications/85214971116#tab=citedBy
U2 - 10.2169/internalmedicine.3672-24
DO - 10.2169/internalmedicine.3672-24
M3 - Article
C2 - 38811222
AN - SCOPUS:85214971116
SN - 0918-2918
VL - 64
SP - 237
EP - 242
JO - Internal Medicine
JF - Internal Medicine
IS - 2
ER -