Edg8/S1P5: An oligodendroglial receptor with dual function on process retraction and cell survival

C. Jaillard, S. Harrison, B. Stankoff, M. S. Aigrot, A. R. Calver, G. Duddy, F. S. Walsh, M. N. Pangalos, N. Arimura, K. Kaibuchi, B. Zalc, C. Lubetzki

研究成果: Article査読

248 被引用数 (Scopus)

抄録

Endothelial differentiation gene (Edg) proteins are G-protein-coupled receptors activated by lysophospholipid mediators: sphingosine-1-phosphate (S1P) or lysophosphatidic acid. We show that in the CNS, expression of Edg8/S1P5, a high-affinity S1P receptor, is restricted to oligodendrocytes and expressed throughout development from the immature stages to the mature myelin-forming cell. S1P activation of Edg8/S1P5 on 04-positive pre-oligodendrocytes induced process retraction via a Rho kinase/collapsin response-mediated protein signaling pathway, whereas no retraction was elicited by S1P on these cells derived from Edg8/S1P5-deficient mice. Edg8/S1P5-mediated process retraction was restricted to immature cells and was no longer observed at later developmental stages. In contrast, S1P activation promoted the survival of mature oligodendrocytes but not of pre-oligodendrocytes. The S1P-induced survival of mature oligodendrocytes was mediated through a pertussis toxin-sensitive, Akt-dependent pathway. Our data demonstrate that Edg8/S1P5 activation on oligodendroglial cells modulates two distinct functional pathways mediating either process retraction or cell survival and that these effects depend on the developmental stage of the cell.

本文言語English
ページ(範囲)1459-1469
ページ数11
ジャーナルJournal of Neuroscience
25
6
DOI
出版ステータスPublished - 09-02-2005
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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