Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

Takeo Yoshikawa; Chiyoko Kunishima; Kazuo Yamada; Toshitaka Nabeshima; Haruo Shibuya; Michio Toru

doi:10.1016/0196-9781(94)90208-9

Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

Takeo Yoshikawa
, Chiyoko Kunishima
, Kazuo Yamada
, Toshitaka Nabeshima
, Haruo Shibuya
, Michio Toru

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

3 被引用数 (Scopus)

抄録

The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

本文言語	英語
ページ（範囲）	471-473
ページ数	3
ジャーナル	Peptides
巻	15
号	3
DOI	https://doi.org/10.1016/0196-9781(94)90208-9
出版ステータス	出版済み - 1994
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
生理学
内分泌学
細胞および分子神経科学

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10.1016/0196-9781(94)90208-9

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title = "Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain",

abstract = "The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.",

keywords = "Cholecystokinin mRNA, Methamphetamine, Phencyclidine, Rat brain",

author = "Takeo Yoshikawa and Chiyoko Kunishima and Kazuo Yamada and Toshitaka Nabeshima and Haruo Shibuya and Michio Toru",

year = "1994",

doi = "10.1016/0196-9781(94)90208-9",

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TY - JOUR

T1 - Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

AU - Yoshikawa, Takeo

AU - Kunishima, Chiyoko

AU - Yamada, Kazuo

AU - Nabeshima, Toshitaka

AU - Shibuya, Haruo

AU - Toru, Michio

PY - 1994

Y1 - 1994

N2 - The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

AB - The acute and long-term effects of a single injection of psychoactive drugs, methamphetamine or phencyclidine, were investigated by Northern blot to assess alterations in the cholecystokinin (CCK) mRNA in three areas of the rat brain. In the frontal cortex, there were no significant changes in CCK mRNA after the drug injection. In contrast, decreases in CCK mRNA were observed in the posterior cortex and the hippocampus from 30 min to 48 h after the drug treatment. The data suggest that CCK gene expression has different sensitivity to these psychoactive drugs within the cortices.

KW - Cholecystokinin mRNA

KW - Methamphetamine

KW - Phencyclidine

KW - Rat brain

UR - https://www.scopus.com/pages/publications/0028238158

UR - https://www.scopus.com/pages/publications/0028238158#tab=citedBy

U2 - 10.1016/0196-9781(94)90208-9

DO - 10.1016/0196-9781(94)90208-9

M3 - Article

C2 - 7937322

AN - SCOPUS:0028238158

SN - 0196-9781

VL - 15

SP - 471

EP - 473

JO - Peptides

JF - Peptides

IS - 3

ER -

Effect of a single injection of psychoactive drugs on CCK mRNA in rat brain

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