Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus

S. Chiba, R. Hashimoto, S. Hattori, M. Yohda, B. Lipska, D. R. Weinberger, H. Kunugi

研究成果: ジャーナルへの寄稿学術論文査読

50 被引用数 (Scopus)

抄録

Altered expression of Disrupted-In-Schizophrenia-1 (DISC1) and dysbindin (DTNBP1), susceptibility genes for schizophrenia, in schizophrenic brain has been reported; however, the possible effect of antipsychotics on the expression levels of these genes has not yet been studied. We measured the mRNA expression levels of these genes in frontal cortex and hippocampus of mice chronically treated with typical and atypical antipsychotics by a real-time quantitative RT-PCR method. We found that atypical antipsychotics, olanzapine and risperidone, in a clinically relevant dose increased DISC1 expression levels in frontal cortex, while a typical antipsychotic, haloperidol, did not. No significant effect on dysbindin expression levels was observed in either brain region. These data suggest that prior evidence of decreased expression of dysbindin in postmortem brain of schizophrenics is not likely to be a simple artifact of antemortem drug treatment. Our results also suggest a potential role of DISC1 in the therapeutic mechanisms of certain atypical antipsychotics.

本文言語英語
ページ(範囲)1337-1346
ページ数10
ジャーナルJournal of Neural Transmission
113
9
DOI
出版ステータス出版済み - 09-2006

All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学

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