Effect of eicosapentaenoic acid ethyl ester on hypothyroid function

M. Makino, N. Oda, N. Miura, S. Imamura, K. Yamamoto, T. Kato, K. Fujiwara, Y. Sawai, K. Iwase, A. Nagasaka, M. Itoh

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Thyroid hormones affect reactions in almost all pathways of lipid metabolism. It has been reported that plasma free fatty acid (FFA) concentration in hypothyroidism is generally within the normal range. In this study, however, we show that plasma FFA concentration in some hypothyroid patients is higher than the normal range. Symptoms of thyroid dysfunction in these individuals were less severe than those of patients with lower plasma FFA concentrations. From these findings we hypothesized that the change in FFA concentration must correlate with thyroid function. Using an animal model, we then examined the effect of highly purified eicosapentaenoic acid ethyl ester (EPA-E), a n-3 polyunsaturated fatty acid derived from fish oil, on thyroid function in 1-methyl-2-imidazolethiol (MMI)-induced hypothyroid rats. Oral administration of EPA-E inhibited reduction of thyroid hormone levels and the change of thyroid follicles in MMI-induced hypothyroid rats. These findings suggest that FFA may affect thyroid functions and EPA-E may prevent MMI-induced hypothyroidism.

本文言語English
ページ(範囲)259-265
ページ数7
ジャーナルJournal of Endocrinology
171
2
DOI
出版ステータスPublished - 2001

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

フィンガープリント

「Effect of eicosapentaenoic acid ethyl ester on hypothyroid function」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル