TY - JOUR
T1 - Effect of Hypothermia on Myocardial Depolarization and Repolarization in Neonates with Hypoxic–Ischemic Encephalopathy Due to Asphyxia
AU - Manabe, Masahiko
AU - Fujino, Masayuki
AU - Kusuki, Hirofumi
AU - Sadanaga, Tsuneaki
AU - Hata, Tadayoshi
AU - Bouda, Hiroko
AU - Miyata, Masafumi
AU - Yoshikawa, Tetsushi
N1 - Funding Information:
This work was supported in part by the Japan Society for the Promotion of Science (KAKENHI) (#26350944).
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2022/12
Y1 - 2022/12
N2 - Therapeutic hypothermia (TH) is effective for neonatal hypoxic–ischemic encephalopathy (HIE). The combination of abnormal myocardial repolarization and fatal arrhythmia in patients with accidental hypothermia has prompted clinical validation of the proarrhythmic potential of TH. However, to our knowledge, there have been few clinical studies on myocardial depolarization and repolarization abnormalities caused by TH in neonates. Therefore, we investigated the effects of TH on neonatal myocardial depolarization and repolarization by capturing the waveform changes in electrocardiograms (ECGs) associated with body temperature (BT) before and after TH. We included three neonates with HIE diagnosed at birth who were treated with TH in our hospital. The heart rate, RR interval, P wave duration, PR interval, QRS duration, QT interval, corrected QT (QTc) interval by Fridericia’s formula, J point-T end (JT) interval, corrected JT (JTc) interval by Fridericia’s formula, T peak-T end (Tpe) interval, Tpe/QT, and QRS/QTc were calculated retrospectively using an ECG. The correlations of ECG parameters recorded concurrently with 33 samples in which BT measurements were confirmed were performed. BT and heart rate were positively correlated (R: 0.589, p = 0.0003). BT was negatively correlated with Tpe/QT (R: − 0.470, p = 0.0058), the QTc interval (R: − 0.680, p < 0.0001), and the corrected JT interval (R: − 0.697, p < 0.0001). TH does not affect atrial or ventricular depolarization but prolongs the ventricular repolarization process in a temperature-dependent manner.
AB - Therapeutic hypothermia (TH) is effective for neonatal hypoxic–ischemic encephalopathy (HIE). The combination of abnormal myocardial repolarization and fatal arrhythmia in patients with accidental hypothermia has prompted clinical validation of the proarrhythmic potential of TH. However, to our knowledge, there have been few clinical studies on myocardial depolarization and repolarization abnormalities caused by TH in neonates. Therefore, we investigated the effects of TH on neonatal myocardial depolarization and repolarization by capturing the waveform changes in electrocardiograms (ECGs) associated with body temperature (BT) before and after TH. We included three neonates with HIE diagnosed at birth who were treated with TH in our hospital. The heart rate, RR interval, P wave duration, PR interval, QRS duration, QT interval, corrected QT (QTc) interval by Fridericia’s formula, J point-T end (JT) interval, corrected JT (JTc) interval by Fridericia’s formula, T peak-T end (Tpe) interval, Tpe/QT, and QRS/QTc were calculated retrospectively using an ECG. The correlations of ECG parameters recorded concurrently with 33 samples in which BT measurements were confirmed were performed. BT and heart rate were positively correlated (R: 0.589, p = 0.0003). BT was negatively correlated with Tpe/QT (R: − 0.470, p = 0.0058), the QTc interval (R: − 0.680, p < 0.0001), and the corrected JT interval (R: − 0.697, p < 0.0001). TH does not affect atrial or ventricular depolarization but prolongs the ventricular repolarization process in a temperature-dependent manner.
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U2 - 10.1007/s00246-022-02916-x
DO - 10.1007/s00246-022-02916-x
M3 - Article
C2 - 35670814
AN - SCOPUS:85131586813
SN - 0172-0643
VL - 43
SP - 1792
EP - 1798
JO - Pediatric Cardiology
JF - Pediatric Cardiology
IS - 8
ER -