Effect of intermittent treatment with human parathyroid hormone 1-34 in SAMP6 senescence-accelerated mice

Y. Washimi, H. Chen, A. Ito, R. Takao, T. Uzawa, Y. Yamamoto, H. Yamada, S. Shoumura

研究成果: Article査読

4 被引用数 (Scopus)

抄録

We examined trabecular and cortical bone in the senescence-accelerated mouse prone 6 (SAMP6) murine model of senile osteoporosis after treatment with human PTH 1-34. Sixteen-week-old female SAMP6 mice were assigned to control and PTH groups. PTH (20 μg/kg) was administered sc 3 times a week for 12 weeks. The control mouse strain, senescence-accelerated mouse resistant 1 (SAMR1), was used for comparison. The femoral metaphysis and diaphysis were used to measure bone mineral density (BMD), analyze the trabecular and the cortical structure by micro-computed tomography, and for conducting the bone strength test. PTH significantly attenuated the loss of BMD, improved the trabecular bone microstructure, and increased the bone strength in the femoral metaphysis. We did not find any differences in the bone strength of the femoral diaphysis after PTH treatment, although the cortical bone volume and cortical thickness were improved. Although the cortical thickness increased, the cortical bone density decreased, likely because of the increase of cortical porosity in the distal metaphysis after administration of PTH.

本文言語English
ページ(範囲)395-400
ページ数6
ジャーナルJournal of Endocrinological Investigation
33
6
DOI
出版ステータスPublished - 06-2010

All Science Journal Classification (ASJC) codes

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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