Effect of keigai-rengyo-to, a Japanese kampo medicine, on neutrophil functions: A possible mechanism of action of keigai-rengyo-to in acne

H. Akamatsu, Y. Asada, T. Horio

研究成果: Article査読

10 被引用数 (Scopus)

抄録

On the basis of recent reports that keigai-rengyo-to (TJ-50), an oral Japanese Kampo (herb) medicine, is clinically effective in treating acne, and that tetracyclines are effective against acne by acting directly as an antioxidant on infiltrated neutrophils, we investigated the effect of TJ-50 on the generation of reactive oxygen species (ROS), using human neutrophils and a cell-free, xanthine-xanthine oxidase system. The species investigated were superoxide radical anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (OH·). In addition, neutrophil chemotaxis, phagocytosis and calcium concentration, [Ca2+]i in neutrophils were also assessed. TJ-50 significantly decreased neutrophil-generated O2-, H2O2, and OH· in a dose-dependent manner. Three kinds of ROS generated in the cell-free system were also reduced in the presence of TJ-50. On the other hand, the medicine did not markedly affect neutrophil chemotaxis, phagocytosis or [Ca2+]i in neutrophils. Our results indicate that the clinical effectiveness of TJ-50 in the treatment of acne may be due partly to its antioxidant action on infiltrated neutrophils.

本文言語English
ページ(範囲)255-265
ページ数11
ジャーナルJournal of International Medical Research
25
5
DOI
出版ステータスPublished - 1997
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生化学
  • 細胞生物学
  • 生化学、医学

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