Effect of minaprine on cycloheximide-induced amnesia in mice

Toshitaka Nabeshima, Kazuaki Kawashima, Tsutomu Kameyama

研究成果: Article査読

17 被引用数 (Scopus)

抄録

The effects of minaprine on cycloheximide-induced amnesia were investigated in a step-down passive avoidance task in mice. Minaprine significantly improved cycloheximide-induced amnesia. This effect was inhibited by scopolamine, but was potentiated by physostigmine. The anti-amnestic effect of minaprine on the cycloheximide-induced memory impairment was also antagonized by a serotonin (5-HT) releaser, p-chloroamphetamine, and by a 5-HT precursor, 5-hydroxytryptophan, whereas a 5-HT1A-selective agonist, 8-hydroxy-2-(di-n-propylamino)tetralin, was inactive. The memory-improving effect of minaprine on cycloheximide-induced amnesia was potentiated by a selective 5-HT2 antagonist, ritanserin. These results suggest that the beneficialeffect of minaprine on cycloheximide-induced amnesia may be related not only to cholinergic but also serotonergic neuronal systems (5-HT2 receptors).

本文言語English
ページ(範囲)249-257
ページ数9
ジャーナルEuropean Journal of Pharmacology
169
2-3
DOI
出版ステータスPublished - 10-10-1989
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学

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