Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus

Yoshimasa Maeno, Masanori Shinzato, Shigeo Nagashima, Susan R. Rittling, David T. Denhardt, Toshimitsu Uede, Koki Taniguchi

研究成果: Article

8 引用 (Scopus)

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We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1β, tumor necrosis factor-α, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.

元の言語English
ページ(範囲)139-144
ページ数6
ジャーナルViral Immunology
22
発行部数2
DOI
出版物ステータスPublished - 01-04-2009

All Science Journal Classification (ASJC) codes

  • Immunology
  • Molecular Medicine
  • Virology

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    Maeno, Y., Shinzato, M., Nagashima, S., Rittling, S. R., Denhardt, D. T., Uede, T., & Taniguchi, K. (2009). Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. Viral Immunology, 22(2), 139-144. https://doi.org/10.1089/vim.2008.0054