TY - JOUR
T1 - Effect of pH on activities of novel β-lactamases and β-lactamase inhibitors against these β-lactamases
AU - Ohsuka, S.
AU - Arakawa, Y.
AU - Horii, T.
AU - Ito, H.
AU - Ohta, M.
PY - 1995
Y1 - 1995
N2 - The effects of acidic conditions on activities of seven β-lactamases- TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)-and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5. However, the activities of PSE-2 and OXA-5 were greatly reduced at pH 5.8. All of the β-lactamase inhibitors tested had poorer inhibitory activities at pH 5.8 than at pH 7.5 except clavulanic acid for TEM-1.
AB - The effects of acidic conditions on activities of seven β-lactamases- TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)-and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5. However, the activities of PSE-2 and OXA-5 were greatly reduced at pH 5.8. All of the β-lactamase inhibitors tested had poorer inhibitory activities at pH 5.8 than at pH 7.5 except clavulanic acid for TEM-1.
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U2 - 10.1128/AAC.39.8.1856
DO - 10.1128/AAC.39.8.1856
M3 - Article
C2 - 7486932
AN - SCOPUS:0029133986
SN - 0066-4804
VL - 39
SP - 1856
EP - 1858
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 8
ER -
