Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

Tomomitsu Tahara, Omiyasu Arisawa, Tomoyuki Shibata, Masakatsu Nakamura, Hiromi Yamashita, Daisuke Yoshioka, Masaaki Okubo, Naoko Maruyama, Toshiaki Kamano, Yoshio Kamiya, Hiroshi Fujita, Mitsuo Nagasaka, Masami Iwata, Kazuya Takahama, Akoto Watanabe, Hiroshi Nakano, Ichiro Hirata

研究成果: Article

8 引用 (Scopus)

抄録

Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

元の言語English
ページ(範囲)485-489
ページ数5
ジャーナルAnticancer research
29
発行部数2
出版物ステータスPublished - 01-02-2009

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Metaplasia
3' Untranslated Regions
Vascular Endothelial Growth Factor A
Stomach
Pylorus
Genes
Pyloric Antrum
Gastritis
Carcinogenesis
Genotype
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Tahara, T., Arisawa, O., Shibata, T., Nakamura, M., Yamashita, H., Yoshioka, D., ... Hirata, I. (2009). Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition. Anticancer research, 29(2), 485-489.
Tahara, Tomomitsu ; Arisawa, Omiyasu ; Shibata, Tomoyuki ; Nakamura, Masakatsu ; Yamashita, Hiromi ; Yoshioka, Daisuke ; Okubo, Masaaki ; Maruyama, Naoko ; Kamano, Toshiaki ; Kamiya, Yoshio ; Fujita, Hiroshi ; Nagasaka, Mitsuo ; Iwata, Masami ; Takahama, Kazuya ; Watanabe, Akoto ; Nakano, Hiroshi ; Hirata, Ichiro. / Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition. :: Anticancer research. 2009 ; 巻 29, 番号 2. pp. 485-489.
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title = "Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition",
abstract = "Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95{\%} CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.",
author = "Tomomitsu Tahara and Omiyasu Arisawa and Tomoyuki Shibata and Masakatsu Nakamura and Hiromi Yamashita and Daisuke Yoshioka and Masaaki Okubo and Naoko Maruyama and Toshiaki Kamano and Yoshio Kamiya and Hiroshi Fujita and Mitsuo Nagasaka and Masami Iwata and Kazuya Takahama and Akoto Watanabe and Hiroshi Nakano and Ichiro Hirata",
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Tahara, T, Arisawa, O, Shibata, T, Nakamura, M, Yamashita, H, Yoshioka, D, Okubo, M, Maruyama, N, Kamano, T, Kamiya, Y, Fujita, H, Nagasaka, M, Iwata, M, Takahama, K, Watanabe, A, Nakano, H & Hirata, I 2009, 'Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition', Anticancer research, 巻. 29, 番号 2, pp. 485-489.

Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition. / Tahara, Tomomitsu; Arisawa, Omiyasu; Shibata, Tomoyuki; Nakamura, Masakatsu; Yamashita, Hiromi; Yoshioka, Daisuke; Okubo, Masaaki; Maruyama, Naoko; Kamano, Toshiaki; Kamiya, Yoshio; Fujita, Hiroshi; Nagasaka, Mitsuo; Iwata, Masami; Takahama, Kazuya; Watanabe, Akoto; Nakano, Hiroshi; Hirata, Ichiro.

:: Anticancer research, 巻 29, 番号 2, 01.02.2009, p. 485-489.

研究成果: Article

TY - JOUR

T1 - Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition

AU - Tahara, Tomomitsu

AU - Arisawa, Omiyasu

AU - Shibata, Tomoyuki

AU - Nakamura, Masakatsu

AU - Yamashita, Hiromi

AU - Yoshioka, Daisuke

AU - Okubo, Masaaki

AU - Maruyama, Naoko

AU - Kamano, Toshiaki

AU - Kamiya, Yoshio

AU - Fujita, Hiroshi

AU - Nagasaka, Mitsuo

AU - Iwata, Masami

AU - Takahama, Kazuya

AU - Watanabe, Akoto

AU - Nakano, Hiroshi

AU - Hirata, Ichiro

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

AB - Background: A complex interaction of host genetic and environmental factors may be relevant in Helicocobacter pylori-related gastric carcinogenesis. We investigated the effect of VEGF gene polymorphisms on the risk of gastric pre-malignant condition. Patients and Methods: The G1612A and C936T polymorphisms in the 3'-untranslated region (3'-UTR) of the VEGF gene were genotyped in 337 cancer-free individuals. The presence of intestinal metaplasia in the gastric antrum was assesed in all. Gastritis scores were also assessed according to the updated Sydney system. Results: The 1612 GA genotype held a significantly higher incidence of intestinal metaplasia in H. pylori-positive individuals more than 65 years of age (OR=4.05, 95% CI=1.08-15.15, p=0.038). The degree of intestinal metaplasia was also higher among individuals with 1612 GA in the same generation (GG vs. GA; 0.98±0.87 vs. 1.55±0.96, p=0.026). Conclusion: The G1612A but not the C936T polymorphism of the VEGF gene is associated with gastric pre-malignant condition in older individuals.

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C2 - 19331191

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JO - Anticancer Research

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SN - 0250-7005

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Tahara T, Arisawa O, Shibata T, Nakamura M, Yamashita H, Yoshioka D その他. Effect of polymorphisms in the 3′-untranslated region (3′-UTR) of VEGF gene on gastric pre-malignant condition. Anticancer research. 2009 2 1;29(2):485-489.